Effects of Keishi-ka-shakuyaku-to (Gui-Zhi-Jia-Shao-Yao-Tang) on Diarrhea and Small Intestinal Movement
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概要
- 論文の詳細を見る
The present study was conducted to determine the characteristics of the effects of Keishi-ka-shakuyaku-to (Gui-Zhi-Jia-Shao-Yao-Tang; TJ-60) on diarrhea. Significant repression was noted by TJ-60 at 1000 mg/kg, p.o.for diarrhea induced by pilocarpine, barium chloride or castor oil. Under normal conditions, TJ-60 did not influence small intestinal transit by its oral treatment even at 1000 mg-kg, however, it dose-dependently improved the acceleration of such transit caused by neostigmine. TJ-60 did not influence the resting tonus in isolated small intestine, but did selectively inhibit low frequency electrostimulated contractions.These results indicate that the antidiarrheal effects of TJ-60 may be due to the inhibition of excessively accelerated small intestinal movement, and that the inhibition of acetylcholine release by parasympathetic nerves is partly involved in the mechanism of this antidiarrheal action.
- 社団法人日本薬学会の論文
- 1999-01-15
著者
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石毛 敦
(株)ツムラ中央研究所
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石毛 敦
株式会社ツムラ 研究本部 医薬評価研究所
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KOMATSU Yasuhiro
Kampo and Pharmacognosy Laboratory, Tsumura Central Laboratories, Tsumura & Co.,
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石毛 敦
ツムラ研究本部 医薬評価研究所
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SHIBAHARA Naotoshi
Department of Kampo Diagnostics, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Un
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ISHIGE Atsushi
株式会社ツムラ 研究本部 医薬評価研究所
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Kase Y
Tsumura Research Laboratories Tsumura & Co.
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Kase Yoshio
国立長寿医療センター研究所 老年病研究部
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Kase Yoshio
Central Research Laboratory Tsumura & Co.
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Ishige A
Tsumura Res. Inst. Ibaraki Jpn
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Ishige Atsushi
Center For Kampo Medicine Keio University School Of Medicine
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Ishige Atsushi
北陸大学 薬 薬物治療
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Ishige Atsushi
Kampo And Pharmacognosy Laboratories Tsumura & Co.
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加瀬 義夫
津村薬理研究所
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KASE Yoshio
Kampo & Parmacognosy Laboratory, Tsumura & Co.
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SASAKI Hiroshi
Kampo & Parmacognosy Laboratory, Tsumura & Co.
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SAITOH Kazuko
Kampo Pharmacology Department, Kampo & Pharmacognosy Laboratory, Central Research Laboratories, Tsum
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Ishige Atsushi
Kampo Pharmacology Department Ii Pharmacognosy Laboratory
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Saito Kazuko
Kampo & Pharmacognosy Laboratory R & D Division Tsumura & Co.
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Komatsu Yasuhiro
Kampo And Pharmacognosy Laboratories Tsumura & Co.
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Shibahara Naotoshi
Department Of Kampo Diagnostics Institute Of Natural Medicine University Of Toyama : 21st Century Co
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Shibahara Naotoshi
Department Of Japanese Oriental (kampo) Medicine Toyama Medical And Pharmaceutical University
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Sasaki Horoshi
Faculty of Agriculture, Tohoku University
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Iizuka A
Central Research Laboratories Tsumura & Co
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Sasaki H
Tsumura Research Institute Tsumura & Co.
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Komatsu Yasuhiro
Kampo & Pharmacognosy Laboratory Tsumura & Co.
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Sasaki Hiroshi
Department Of Agricultural Chemistry Faculty Of Agriculture Hokkaido University
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Sasaki Hiroshi
金沢大学 自然科学研究科臨床薬学
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Saitoh K
Kampo Pharmacology Department Ii Pharmacognosy Laboratory
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Ishige Atsushi
Kampo & Pharmacognosy Laboratory R & D Division, Tsumura & Co.
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