Effect of a traditional Chinese medicine, maobushisaishinto, on the antibody titer after influenza vaccination: A randomized, placebo-controlled, double-blind trial
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概要
- 論文の詳細を見る
これまでに動物実験や高齢者に対する非盲検試験で,麻黄附子細辛湯のインフルエンザワクチンに対するアジュバント効果が報告されているが,より精度の高い臨床試験で検討されたことはない。そこで今回,20〜71才の健常者47人を対象として,麻黄附子細辛湯の血清中抗インフルエンザウイルス抗体価に対する影響について検討した。被験者を無作為に実薬群(n=23)とプラセボ群(n=24)に振り分け,二重盲検法にて実薬またはプラセボを2週間投与したところで,ワクチンを接種した。その後採血を0,1,2,4,12週目に行い,上記抗体価を測定した。ワクチン接種後のインフルエンザ抗体価はA型(H3N2, H1N1), B型ともに実薬群で有意に優れているとは言えなかった。今後世界中で鳥インフルエンザのヒトへの感染とその流行が予想され,アジュバント効果がある薬剤の重要性が極めて大きくなる。他のアジュバント効果を持つものの検討が必要である。
著者
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Hamazaki Kei
Section Of Clinical Application Department Of Clinical Sciences Institute Of Natural Medicine Univer
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浜崎 智仁
富山医薬大 和漢薬研
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SHIBAHARA Naotoshi
Department of Kampo Diagnostics, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Un
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TERASHIMA Yoshihiro
Section of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, Uni
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ITOMURA Miho
Section of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, Uni
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HUAN Mingming
Section of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, Uni
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KOBAYASHI Satoru
Department of Pharmacy, University Hospital, Tokyo Medical and Dental University
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浜崎 智仁
富山大学和漢医薬学総合研究所臨床科学研究部門臨床利用分野
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Itomura Miho
Section Of Clinical Application Department Of Clinical Sciences Institute Of Natural Medicine Univer
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Huan Mingming
Section Of Clinical Application Department Of Clinical Sciences Institute Of Natural Medicine Univer
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浜崎 智仁
日本水産
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Shibahara Naotoshi
Department Of Kampo Diagnostics Institute Of Natural Medicine University Of Toyama
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Shibahara Naotoshi
Department Of Japanese Oriental (kampo) Medicine Toyama Medical And Pharmaceutical University
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Shibahara Naotoshi
Department Of Kampo Diagnostics Toyama Medical And Pharmaceutical University
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Terashima Yoshihiro
Section Of Clinical Application Department Of Clinical Sciences Institute Of Natural Medicine Univer
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Kobayashi Satoru
Department Of Pediatrics And Neonatology Nagoya City University Graduate School Of Medical Sciences
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浜崎 智仁
富山大学和漢医薬学総合研究所
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Kobayashi Satoru
Department Of Pharmacy University Hospital Tokyo Medical And Dental University
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Kobayashi Satoru
Department Biology Tokyo Metropolitan Institute Of Gerontology
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