Bofutsushosan, a traditional Chinese formulation, inhibits pancreatic lipase activity in vitro and suppresses the elevation of plasma triacylglycerols after oral administration of lipid emulsion
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概要
- 論文の詳細を見る
Pancreatic lipase activity measured as fatty acid liberation from lipid emulsion was shown to be inhibited by the addition of Bofutsushosan (BOF) or Daijokito (DJT) extracts at >30mg/ml. The extracts of Orengedokuto (OGT), Chotosan (CTS), Boiogito (BOT) or Shimbuto (SBT) were ineffective in inhibiting pancreatic lipase activity up to 60mg/ml. Mice were orally administered with a lipid emulsion in the presence of BOF extracts at 750 and 2250mg/kg and subsequent elevation of plasma triacylglycerols (TAG) was significantly suppressed as compared with that in the mice which received lipid emulsion alone. However, the addition of DJT extracts did not suppress the elevation of plasma TAG after oral administration of lipid emulsion. Our results suggest that BOF suppresses the absorption of ingested fats and this effect could account for the anti-obese effects of BOF.21st Century COE program, University of Toyama
- 和漢医薬学会の論文
- 2005-12-20
著者
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Hamazaki Kei
Section Of Clinical Application Department Of Clinical Sciences Institute Of Natural Medicine Univer
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浜崎 智仁
富山医薬大 和漢薬研
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SAITO MASATAKA
Department of Anesthesiology, Nagasaki University School of Medicine
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Saito Masataka
Department Of Anesthesiology Nagasaki University School Of Medicine
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Tani T
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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谿 忠人
和漢薬研究所資源開発研究部門
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Saito Masataka
Department Of Clinical Sciences University Of Toyama
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浜崎 智仁
日本水産
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渡辺 志朗
富山大学和漢医薬学総合研究所臨床利用分野
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HAMAZAKI Tomohito
Department of Clinical Sciences, University of Toyama
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TANI Tadato
Century COE program, University of Toyama
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TANI Tadato
富山医科薬科大学和漢薬研究所資源開発部門
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浜崎 智仁
富山大学和漢医薬学総合研究所
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Hamazaki Tomohito
Univ. Toyama Toyama Jpn
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Hamazaki Tomohito
Department Of Clinical Application Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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Tani Tadato
Department Of Kampo Pharmaceutics Institute Of Natural Medicine Toyama Medical And Pharmaceutical Un
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Tani Tadato
Department Of Kampo Pharmaceutics Institute Of Natural Medicine University Of Toyama:21^<st> C
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Tani Tadato
Department Of Kampo-pharmaceutics Institute Of Natural Medicine University Of Toyama
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Tani Tadato
Department Of Pharmacognosy Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universi
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