Differential Effects of Selective Cyclooxygenase (COX)-1 and COX-2 Inhibitors on Anorexic Response and Prostaglandin Generation in Various Tissues Induced by Zymosan(Biochemistry)

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概要

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• We have shown that anorexic response is induced by intraperitoneal injection of zymosan in mice, although the role of prostaglandins in this response is relatively unknown as compared with lipopolysaccharide (LPS)-induced anorexic response. Indomethacin (0.5 and 2.0mg/kg), a non-selective cyclooxygenase (COX) inhibitor, as well as meloxicam (0.5mg/kg), a selective COX-2 inhibitor, but not FR122047 (2.0mg/kg), a selective COX-1 inhibitor, attenuated zymosan-induced anorexia. Zymosan injection elevated COX-2 expression in brain and liver but not in small intestine and colon. Meloxicam (0.5mg/kg) and FR122047 treatment (2.0mg/kg) similarly suppressed the generation of brain prostaglandin E_2 (PGE_2) and peritoneal prostacyclin (PGI_2) upon zymosan injection. PGE_2 generation in liver upon zymosan injection was suppressed by meloxicam (0.5mg/kg) but not by FR122047 treatment (2.0mg/kg). Our observations suggest that COX-2 plays an important role in zymosan-induced anorexia, which is a similar feature in LPS-induced anorexic response. However, non-selective inhibition by selective COX-1 and COX-2 inhibitors of brain PGE_2 generation upon zymosan injection does not support the role of COX-2 expressed in brain in zymosan-induced anorexic response. PGE_2 generation in liver may account for peripheral role of COX-2 in zymosan-induced anorexic response.

• 公益社団法人日本薬学会の論文
• 2006-07-01

著者

• SAITO MASATAKA

  Department of Anesthesiology, Nagasaki University School of Medicine

• Saito Masataka

  Department Of Anesthesiology Nagasaki University School Of Medicine

• Saito Masataka

  Department Of Clinical Application Institute Of Natural Medicine University Of Toyama

• WATANABE Shiro

  Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University

• HAMAZAKI Tomohito

  Department of Clinical Sciences, University of Toyama

• NAOI Kazuhisa

  Department of Clinical Application, Institute of Natural Medicine, University of Toyama

• KOGURE Suguru

  Department of Clinical Application, Institute of Natural Medicine, University of Toyama

• Hamazaki Tomohito

  Department Of Clinical Application Institute Of Natural Medicine University Of Toyama

• Hamazaki Tomohito

  Department Of Clinical Application Institute Of Natural Medicine Toyama Medical And Pharmaceutical U

• Kogure Suguru

  Department Of Clinical Application Institute Of Natural Medicine University Of Toyama

• Naoi Kazuhisa

  Department Of Clinical Application Institute Of Natural Medicine University Of Toyama

• Watanabe Shiro

  Department Of Clinical Application Institute Of Natural Medicine University Of Toyama:21st Coe Progr

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