Effect of Replacing a High Linoleate Oil with a Low Linoleate, High α-Linolenate Oil, as Compared with Supplementing EPA or DHA, on Reducing Lipid Mediator Production in Rat Polymorphonuclear Leukocytes
スポンサーリンク
概要
- 論文の詳細を見る
The fatty acid composition of rat polymorphonuclear leukocytes (PMN) was modified by diets supplemented with a high linoleate (LA) safflower oil (76% LA), mixtures of eicosapentaenoate (EPA) and safflower oil (EPA(20) containing 20% EPA and 61% LA, EPA(40) containing 40% EPA and 46% LA), mixtures of docosahexaenoate (DHA) and safflower oil (DHA(20) containing 20% DHA and 61% LA, DHA(40) containing 40% DHA and 46% LA) or a high α-linolenate (α-LNA)perilla oil (57% α-LNA and 13% LA), and then lipid mediator production in casein-induced peritoneal PMN were compared. EPA and DHA were relatively ineffective in reducing platelet-activating factor (PAF) production; a statistically significant reduction was observed only in the DHA(40) group. In contrast, perilla oil reduced PAF production by 50% as compared with safflower oil. Arachidonate (AA) in the PAF precursor, 1-alkyl-2-acyl-glycerophosphocholine, was roughly correlated with PAF production, but EPA and DHA in the precursor lipid were relatively unrelated. On the other hand, both PGE_2 and LTB_4 production correlated positively with AA and negatively with EPA and DHA in PMN phospholipids; EPA tended to be somewhat more effective than DHA in reducing PGE_2 and LTB_4 formation; the activity of perilla oil was no less than EPA(20). Thus, replacing safflower oil with perilla oil was no less effective than supplementing safflower oil with EPA or DHA (at 40% of total fatty acids) in reducing lipid mediator production in rat PMN.
- 公益社団法人日本薬学会の論文
- 1998-06-15
著者
-
OKUYAMA Harumi
Department of Preventive Nutraceutical Sciences, Nagoya City University, Graduate School of Pharmace
-
OKUYAMA Harumi
Open Research Center for Lipid Nutrition, Kinjo Gakuin University College of Pharmacy
-
Takahashi Tetsuya
Department of Internal Medicine, Chibune Hospital
-
Kobayashi Tetsuyuki
Department of Biological Sciences, Graduate School of Humanities and Sciences, Ochanomizu University
-
Okuyama H
Nagoya City Univ. Nagoya Jpn
-
Okuyama Harumi
Department Of Biological Chemistry Faculty Of Pharmaceutical Science Nagoya City University
-
Okuyama Harumi
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
-
WATANABE Shiro
Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University
-
Hata Noriaki
Applied Research Department Harima Chemicals Inc.
-
MISAWA Yoshihisa
Applied Research Department, Harima Chemicals Inc.
-
Kameyama Tsutomu
Faculty Of Pharmaceutical Sciences Nagoya City University
-
OH-HASHI Kentaro
Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University
-
Oh-hashi Kentaro
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
-
Takahashi Tetsuya
Department Of Avian Endocrinology Gifu University
-
Takahashi Tetsuya
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
-
Kameyama T
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
-
Misawa Yoshihisa
Applied Research Department Harima Chemicals Inc.
-
Kameyama Tsutomu
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
-
Misawa Y
Applied Research Department Harima Chemicals Inc.
-
Kameyama Tsutomu
Dept. Of Chem. Pharmaco. Meijo Univ.
-
Watanabe Shiro
Department of Preventive Nutraceutical Sciences, Graduate School of Pharmaceutical Sciences Nagoya City University
関連論文
- Cervical Epidural Abscess Presenting with Brown-Sequard Syndrome in a Patient with Type 2 Diabetes
- Inhibition of cell proliferation by nobiletin, a dietary phytochemical, associated with apoptosis and characteristic gene expression, but lack of effect on early rat hepatocarcinogenesis in vivo
- Testosterone-lowering activity of canola and hydrogenated soybean oil in the stroke-prone spontaneously hypertensive rat
- Characterization of a 62-Kilodalton Acidic Phospholipid-Binding Protein Isolated from the Edible Mushroom Pleurotus ostreatus
- Association between central systolic blood pressure, white matter lesions in cerebral MRI and carotid atherosclerosis
- Diagonal Ear-Lobe Crease is Correlated With Atherosclerotic Changes in Carotid Arteries
- Protrein Carbonyl Content Roughly Reflects the Unsaturation of Lipids in Muscle but Not in Other Tissues of Stroke-Prone Spontaneously Hypertensive Strain (SHRSP) Rats Fed Different Fats and Oils
- Effect of Rapessed and Dietary Oils on the Mean Survival Time of Stroke-Prone Spontaneously Hypertensive Rats
- Effects of Dietary Vegetable Oils on Behavior and Drug Responses in Mice
- Cardiopulmonary Responses at Various Angles of Cycle Backrest Inclination
- Hepatic resection for colorectal metastases in the caudate lobe of the liver
- Cardiopulmonary Response during Supine and Sitting Bicycle Exercises
- PE-166 Does Respiratory Muscle Strength Relate to Exercise Capacity in Patients with Chronic Heart Failure?(Exercise test/Cardiac rehabilitation-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Does Respiratory Muscle Function Relate to Increased Exercise Ventilation after Cardiac Surgery?
- Human beta defensin-3 engineered keratinocyte sheets constructed by a magnetic force-based tissue engineering technique(CELL AND TISSUE ENGINEERING)
- Nutritional Evaluation of an Inter-Esterified Perilla Oil and Lard in Comparison with Butter and Margarine Based on the Survival of Stroke-Prone Spontaneously Hypertensive (SHRSP) Rats
- Long-term survival in a patient with hepatocellular carcinoma with resection of a metastatic lymph node after percutaneous ethanol injection therapy
- A-5 EFFECT OF 3,4-METHYLENEDIOXYMETHAMPHETAMINE (MDMA) ON STEREOTYPED BEHAVIORS AND NEUROTRANSMITTER RELEASE INTO RAT BRAIN DIALYSATE IN VIVO
- C16 STEREOTYPED BEHAVIORS INDUCED BY PHENCYCLIDINE (PCP)-DERIVATIVES
- Synthesis of Deuterium-Labeled Flavanones
- Cholesteryl Glucoside-induced Protection against Gastric Ulcer
- Effective Biosynthesis of Poly(3-hydroxybutyrate) from Plant Oils by Chromobacterium sp.
- Supplementary Treatment of Atopic Dermatitis Patients by Choosing Foods to Lower the N-6/N-3 Ratio of Fatty Acids
- EFFECTS OF APOMORPHINE ON MORPHINE ANALGESIA DURING THE STATE OF DOPAMINERGIC SUPERSENSITIVITY AFTER CHRONIC TREATMENT WITH HALOPERIDOL
- Successful Treatment of Recurrent Liver Metastases from Gastric Cancer by Repeated Hepatic Resections : Report of a Case
- Effects of Dietary Unsaturated Fatty Acid and Chronic Carbon Tetrachloride Treatment on the Accumulation of Oxidation Products, α-Tocopherol and Liver Injury in Mice
- A High Linoleate and a High α-Linolenate Diet Induced Changes in Learning Behavior of Rats. Effects of a Shift in Diets and Reversal of Training Stimuli
- Cholesterol Synthesis in Mice Is Suppressed but Lipofuscin Formation Is Not Affected by Long-Term Feeding of n-3 Fatty Acid-Enriched Oils Compared with Lard and n-6 Fatty Acid-Enriched Oils
- Dietary n-3 Fatty Acid Deficiency Decreases Nerve Growth Factor Content in Rat Hippocampus.
- n-6/n-3 Ratio of Dietary Fatty Acids Rather Than Hypercholesterolemia As the Major Risk Factor for Atherosclerosis and Coronary Heart Disease
- Long-termn n-3 Fatty Acid Deficiency Induces No Substantial Change in the Rate of Protein Synthesis in Rat Brain and Liver
- Orally Active NGF Synthesis Stimulators : Potential Therapeutic Agents in Alzheimer's Disease.
- Steryl Glucoside is a Lipid Mediator in Stress-responsive Signal Transduction
- Clinical relevance of central systolic blood pressure and augmentation index : comparison with carotid echo parameters
- Effect of Dietary Docosahexaenoic Acid on In Vitro Thermogenesis and Fatty Acid Compositions of Brown Adipose Tissue
- Effect of Dietary Essential Fatty Acids on Pulmonary Metastasis of Ascites Tumor Cells in Rats(Biological)
- Effect of growth hormone on estrogen receptor binding properties in the chick oviduct in vivo
- DESIGN OF A PHENCYCLIDINE IMPLANTATION PELLET : SUITABLE FOR TOLERANCE DEVELOPMENT
- MECHANISM OF TOLERANCE DEVELOPMENT TO PENTOBARBITAL IN RELATION TO GABA-ERGIC NEURONAL AND DISPOSITIONAL FUNCTIONS IN MICE
- MECHANISM OF TOLERANCE DEVELOPMENT TO PHENCYCLIDINE IN RELATION TO GABA-ERGIC NEURONAL AND DISPOSITIONAL FUNCTIONS IN MICE
- Denervation of Dopaminergic Neurons with 6-Hydroxydopamine Increases Nerve Growth Factor Content in Rat Brain.
- Effect of Replacing a High Linoleate Oil with a Low Linoleate, High α-Linolenate Oil, as Compared with Supplementing EPA or DHA, on Reducing Lipid Mediator Production in Rat Polymorphonuclear Leukocytes
- Reevaluation of the Effect of a High α-Linolenate and a High Linoleate Diet on Antigen-Induced Antibody and Anaphylactic Responses in Mice
- AN ENZYME IMMUNOASSAY FOR PROSTAGLANDIN E_2 USING BIOTIN-PROSTAGLANDIN B_2 CONJUGATE AS A TRACER
- Metabolic balance of streams draining urban and agricultural watersheds in central Japan
- EXPRESSION OF TELOMERASE ACTIVITY ASSOCIATED WITH TRANSFORMATION OF HUMAN FIBROBLASTS
- DEVELOPMENT OF AMNESIA MODEL FOR SCREENING OF NOOTROPIC DRUGS AND EFFECTS OF MEVALONIC-GABA ON LEARNING AND MEMORY IN MICE
- EFFECTS OF DIAZEPAM, MEPROBAMATE, CHLORPROMAZINE AND APOMORPHINE ON A QUICKLY LEARNED CONDITIONED SUPPRESSION IN MICE
- Conditioned Suppression of Motility : Possibility for Evaluation of Learning and Memory in Mice
- STIMULATION OF Gq PROTEIN-COUPLED SIGNAL TRANSDUCTION BY CYCLIC PHOSPHATIDIC ACID (cPA) AND ACTIVATION OF PROTEIN KINASE C IN VITRO
- Differential Effects of Selective Cyclooxygenase (COX)-1 and COX-2 Inhibitors on Anorexic Response and Prostaglandin Generation in Various Tissues Induced by Zymosan(Biochemistry)
- Enhanced Learning of Normal Adult Rodents by Repeated Oral Administration of Soybean Transphosphatidylated Phosphatidylserine
- Effects of Prenatal Administration of Phencyclidine on the Learning and Memory Processes of Rat Offspring
- DOPAMINERGIC INVOLVEMENT IN PHENCYCLIDINE-INDUCED STEREOTYPED BEHAVIOR
- EFFECTS OF NARCOTIC AND NON-NARCOTIC ANALGESICS ON THE ABDOMINAL OR TAIL STIMULATION-INDUCED STRUGGLING IN RATS
- Calcitonin Directly Inhibits Luteinizing Hormone-Stimulated Progesterone Production in Granulosa Cells of the Largest Follicle of Hens
- Memory Impairment in Rats Induced by an Active Fragment of Nerve Growth Factor Antibody.
- IMPAIRMENT OF ACTIVE AVOIDANCE RESPONSE IN RATS WITH CONTINUOUS INFUSION OF QUINOLINIC ACID INTO THE LATERAL VENTRICLE
- EFFECTS OF CATECHOLAMINERGIC OR TRYPTAMINERGIC AGENTS ON THE MORPHINE-INDUCED STRAUB TAIL REACTION
- Neurokinin A and Senktide Attenuate Acopolamine-Induced Impairment of Spontaneous Alternation Performance in Mice
- Opioid Receptor Agonists Selective for μ and κ Receptors Attenuate Methamphetamine-Induced Behavioral Sensitization in the Mouse
- Memory Impairment and Morphological Changes in Rats Induced by Active Fragment of Anti-nerve Growth Factor-antibody.
- Aged-Related Changes in Learning and Memory, Choline Acetyltransferase Activity and Number of Neuronal Cells in Rats
- Apple Polyphenols Influence Cholesterol Metabolism in Healthy Subjects with Relatively High Body Mass Index
- Application of a New Muscle Exercise Device using Intermittent Sole Pressure Stimulation
- Effects of Nerve Growth Factor (NGF) in Rats with Basal Forebrain Lesions.
- CONDITIONED SUPPRESSION AND OPIOID KAPPA RECEPTOR IN MICE
- Chiisanoside Is Not Absorbed but Inhibits Oil Absorption in the Small Intestine of Rodents
- OTOTOXICITY INDUCED BY PRE-AND POSTNATAL EXPOSURE TO AMINOGLYCOSIDE ANTIBIOTICS
- SOME ASPECTS OF METABOLISM OF PHOSPHOLIPID ACYL CHAINS IN THROMBIN-STIMULATED PLATELETS
- A MODE OF ACTION OF MORPHINE ON A QUICKLY LEARNED CONDITIONED SUPPRESSION IN MICE
- EFFECTS OF ANALGESICS AND CNS-ACTING DRUGS ON STRUGGLING FOLLOWING REPETITIVE STIMULATION OF THE TAIL, AND FLEXOR REFLEX TO A SINGLE STIMULATION OF THE SCIATIC NERVE IN RATS
- CHANGE IN CATECHOLAMINE-SENSITIVE Na+, K+-ATPase ACTIVITY IN THE RAT STRIATUM MICROSOMES FOLLOWING ELECTROLYTIC OR 6-HYDROXYDOPAMINE-INDUCED LESIONS OF DOPAMINERGIC NEURONS
- ROLE OF DOPAMINERGIC AND SEROTONERGIC NEURONAL SYSTEMS IN THE PREFRONTAL CORTEX OF RATS IN PHENCYCLIDINE-INDUCED BEHAVIORS
- ROLE OF DOPAMINERGIC AND GABAERGIC MECHANISMS IN DISCRETE BRAIN AREAS IN PHENCYCLIDINE-INDUCED LOCOMOTOR STIMULATION AND TURNING BEHAVIOR
- INVOLVEMENT OF OPIOID RECEPTORS IN HYPO- AND HYPER-THERMIC EFFECTS INDUCED BY PHENCYCLIDINE IN MICE
- EFFECTS OF DIFENAMIZOLE ON CONTENT OF CATECHOLAMINES AND METABOLITES IN MOUSE BRAIN
- CORRELATION BETWEEN THE 5-HYDROXYTRYPTAMINE CONTENTS IN THE BRAIN AND DEGREES OF SENSORY, AND LOCOMOTOR ACTIVITIES IN THE RAT
- PHARMACOLOGICAL STUDIES OF FURO [3,2-b] INDOLE DERIVATIVES. II. ANALGESIC EFFECT OF FI-302,N-(3-PIPER-IDINOPROPYL)-4-METHYL-6-TRIFLUOROMETHYL-FURO [3,2-b] INDOLE-2-CARBOXAMIDE, IN EXPERIMENTAL ANIMALS
- PHARMACOLOGICAL STUDIES OF FURO [3,2-b] INDOLE DERIVATIVES. I. ANALGESIC, ANTI-PYRETIC AND ANTI-INLAMMATORY EFFECTS OF FI-302,N-(3-PIPERIDINOPROPYL)-4-METHYL-6-TRIFLUOROMETHYL-FURO [3,2-b] INDOLE-2-CARBOXAMIDE, IN EXPERIMENTAL ANIMALS
- Biological Functions of a Novel Lipid Mediator, Cyclic Phosphatidic Acid (cPA)
- Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by In Vitro Autoradiography (2): Changes in GABAA and Benzodiazepine Receptor Binding
- Calcitonin receptor binding in the hen anterior pituitary during an oviposition cycle
- Effect of calcitonin on adrenocorticotropic hormone secretion stimulated by corticotropin-releasing hormone in the hen anterior pituitary
- Molecular Characterization and Mutational Analysis of Recombinant Diadenosine 5′,5″-P1,P4-Tetraphosphate Hydrolase from Plasmodium falciparum
- Validity and Reliability Assessment of a Japanese Version of the Snaith-Hamilton Pleasure Scale
- Growth and Ferromagnetic Properties of Ferroelectric YbMnO3 Thin Films
- Butanol extracts from myelin fragements: some characteristics of tryptamine binding.
- In vivo voltammetric study of dopamine release in the striatum following microinjection of apomorphine into the substantia nigra zona reticulata.
- Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by In Vitro Autoradiography (1): Changes in the (3H)QNB Binding.
- Effects of Nerve Growth Factor(NGF) in Rats with Basal Forebrain Lesions.
- Effects of methamphetamine on dopamine cells in the substantia nigra pars compacta and the ventral tegmental area.
- Lifetime risk of stroke and impact of hypertension : estimates from the adult health study in Hiroshima and Nagasaki