Effect of Dietary Essential Fatty Acids on Pulmonary Metastasis of Ascites Tumor Cells in Rats(Biological)
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概要
- 論文の詳細を見る
Rats were fed a semi-purified diet supplemented either with a linoleic acid-rich oil (safflower oil) or with an α-linolenic acid-rich oil (perilla oil) from weanling to 7 weeks of age. Rats fed a conventional diet were also used as controls. Ascites tumor cells were injected intravenously into these rats and the numbers of metastatic foci on the pulmonary surface were determined macroscopically. The average number of metastatic foci was significantly less in the rats fed the perilla oil diet than in the rats fed the safflower oil diet or the conventional diet. Combined with previous results on the metastatic potentials of tumor cells modified with different fatty acids, these results indicate that the modification of host animal cells by dietary fatty acids also affects the metastatic potentials of the ascites tumor cells in rats, apparently independently of the tumor cell modifications caused by the supplemented fatty acids.
- 公益社団法人日本薬学会の論文
- 1987-09-25
著者
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OKUYAMA Harumi
Department of Preventive Nutraceutical Sciences, Nagoya City University, Graduate School of Pharmace
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Koizumi Tamiya
Laboratory Of Cancer Cell Biology Nagoya University School Of Medicine
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Hori T
Nagasaki Univ. Nagasaki Jpn
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Hori Takamitsu
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hiroshima International University
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Okuyama Harumi
Department Of Biological Chemistry Faculty Of Pharmaceutical Science Nagoya City University
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MORIUCHI ATSUKO
Department of Biological Chemistry, Faculty of Pharmaceutical Science, Nagoya City University
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SOBAJIMA TAKESHI
Laboratory of Cancer Cell Biology, Nagoya University School of Medicine
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KOJIMA KIYOHIDE
Laboratory of Cancer Cell Biology, Nagoya University School of Medicine
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Kojima K
Sankyo Co. Ltd. Tokyo Jpn
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Moriuchi Atsuko
Department Of Biological Chemistry Faculty Of Pharmaceutical Science Nagoya City University
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Sobajima Takeshi
Laboratory Of Cancer Cell Biology Nagoya University School Of Medicine
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