Effects of Dietary Unsaturated Fatty Acid and Chronic Carbon Tetrachloride Treatment on the Accumulation of Oxidation Products, α-Tocopherol and Liver Injury in Mice
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概要
- 論文の詳細を見る
Mice, at weaning, were placed on a diet supplemented with beef tallow (BT), linoleic acid (18 : 2n-6)-rich saffower oil (SO), α-linolenic acid (18 : 3n-3)-rich perilla oil (PO) or docosahexaenoic acid (22 : 6n-3,DHA)-rich fish oil (FO) to modify membrane fatty acid vulnerability to peroxidation, then carbon tetrachloride (CCl_4) was administered chronically. CCl_4-induced liver injury, estimated using serum alanine aminotransferase activity and liver hydroxyproline content, was not different among the 4 dietary groups; however, the FO diet lowered the liver triacylglycerol (TG) level when compared with the BT and SO diets. The FO diet group exhibited a significantly higher level of thiobarbituric acid-reactive substances (TBARS) in the liver when compared with the three other dietary groups. Chronic CCl_4 treatment decreased the proportion of eicosanoid precursors (arachidonate and eicosapentaenoate) rather than that of DHA, with the highest peroxidizability among major fatty acids in liver, and did not enhance TBARS formation in any of the dietary groups. The protein carbonyl content in the liver was similar among the 4 dietary groups but was decreased following CCl_4 treatment. Liver α-tocopherol contents were affected both by diet and CCl_4 treatment, and a positive correlation was observed between α-tocopherol and TG contents. These results indicate that increasing the autoxidizability of dietary fatty acids or the chronic CCl_4 treatment did not synergistically enhance liver injury or the accumulation of oxidation products in mice.
- 公益社団法人日本薬学会の論文
- 1998-10-15
著者
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Yasuda Satoshi
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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OKUYAMA Harumi
Department of Preventive Nutraceutical Sciences, Nagoya City University, Graduate School of Pharmace
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OKUYAMA Harumi
Open Research Center for Lipid Nutrition, Kinjo Gakuin University College of Pharmacy
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Yoshizumi S
Research And Development Headquaters Hokuriku Seivaku Co. Ltd.
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Kobayashi Tetsuyuki
Department of Biological Sciences, Graduate School of Humanities and Sciences, Ochanomizu University
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Yasuda S
Kanazawa Univ. Kanazawa Jpn
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Yasuda Shingo
Research And Development Division Hokuriku Seiyaku Co. Ltd.
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Okuyama H
Nagoya City Univ. Nagoya Jpn
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Okuyama Harumi
Open Research Center For Lipid Nutrition Kinjo Gakuin University College Of Pharmacy
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Okuyama Harumi
Department Of Biological Chemistry Faculty Of Pharmaceutical Science Nagoya City University
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Okuyama Harumi
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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WATANABE Shiro
Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University
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Yasuda Satoshi
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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Kameyama Tsutomu
Faculty Of Pharmaceutical Sciences Nagoya City University
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Yasuda Satoshi
Department Of Biochemistry Sapporo Medical University School Of Medicine
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Kameyama T
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
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Kameyama Tsutomu
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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Kameyama Tsutomu
Dept. Of Chem. Pharmaco. Meijo Univ.
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Watanabe Shiro
Department of Preventive Nutraceutical Sciences, Graduate School of Pharmaceutical Sciences Nagoya City University
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