Reevaluation of the Effect of a High α-Linolenate and a High Linoleate Diet on Antigen-Induced Antibody and Anaphylactic Responses in Mice

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Previously, we reported that a high α-linolenate [18 : 3(n-3)] diet compared with a high linoleate [18 : 2(n-6)] diet suppressed the anti-egg albumin (EA) immunoglobulin E (IgE) antibody response in mice. Because of relatively high background values obtained with the method used previously, we used an improved ELISA and once again determined serum IgE levels. In contrast to our previous results, the serum levele of anti-dinitrophenyl specific (anti-DNP) as well as total IgE in mice immunized with DNP-antigen was slightly but significantly heigher in the high α-linolenate diet group than in the high linoleate diet group. Anti-DNP IgG_1 and IgG_<2a> antibody responses were not significantly different in mice fed these diets. Indomethacin administration during immunization tended to enhance the IgE antibody responses. The mortality of mice from antigen-induced anaphylatic shock was significantly lower in the high α-linolenate diet group than in the high linoleate diet group; however, there was no difference between the groups in terms of vascular permeability and histamine levels. Thus, the high α-linolenate diet enhances the IgE antibody response slightly without affecting either the IgG antibody response, vascular permeability or histamine release. The high α-linolenate diet possibly suppress anaphylactic shock by reducing the synthesis of lipid mediators such as eicosanoids and platelet-activating factor.
公益社団法人日本薬学会の論文
1997-03-15

Reevaluation of the Effect of a High α-Linolenate and a High Linoleate Diet on Antigen-Induced Antibody and Anaphylactic Responses in Mice

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