EXPRESSION OF TELOMERASE ACTIVITY ASSOCIATED WITH TRANSFORMATION OF HUMAN FIBROBLASTS

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概要

• 論文の詳細を見る

• Telomerase activity and telomere length in normal and immortalized human fibroblasts were determined. In normal cells, no telomerase activity was detected, but after transformation of these cells with SV40 or ^<60>Co, cells changed into immortal and an apparent telomerase activity expressed. Telomere length of these cells were determined and a distinct shortening of telomeres was observed in one case of transformants,and in other cases, telomere elongation was observed. DNA polymerase α activity was also determined, and high activity was detected in the cells having long telomeres, but low activity was detected in the cells bearing short telomeres. The expression of telomerase may be required as a critical step for tumorgenesis, but telomere length may not be a determinants of malignancy of tumor cells.

• お茶の水女子大学の論文

著者

• Shimada Yukiko

  Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University

• Kobayashi Tetsuyuki

  Department of Biological Sciences, Graduate School of Humanities and Sciences, Ochanomizu University

• Murakami-Murofushi Kimiko

  Department of Biology, Faculty of Science, Ochanomizu University

• Shimada Yukiko

  Depertment Of Biology Faculty Of Science Ochanomizu University

• Shimada Yukiko

  Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University

• Nakano Mariko

  Department of Electrical Engineering, Universidad Autonoma Metropolitana

• Nakano Mariko

  Department Of Biology Faculty Of Science Ochanomizu University

• Murakami‐murofushi K

  Department Of Biology Fscutry Of Science Ochanomizu University

• Murakami-murofushi Kimiko

  Department Of Biology Faculty Of Science Ochanomizu University

• Kobayashi Tetsuyuki

  Department Of Biology Faculty Of Science Ochanomizu University

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