TELOMERE AND TELOMERASE IN HUMAN LEUKOCYTES AND IMMORTAL CELL LINES
スポンサーリンク
概要
- 論文の詳細を見る
Telomere length and telomerase activity were determined in peripheral blood leukocytes isolated from normal donors and human, immortal leukemic cell lines derived from different cell sources. Telomeres in normal leukocytes had shorten with age of donors but no telomerase activity was detected in these cells. An apparent shortening of telomeres was observed in most of immortal cells, and they showed telomerase activity with a high processivity. The expression of telomerase may be required as a critical step for tumorgenesis, but telomere length may not be a determinants of malignancy of cancer cells. The enzyme activitywas sensitive to pretreatment with RNase A and proteinase K, suggesting the nature of this enzyme as a ribonucleoprotein.
- お茶の水女子大学の論文
著者
-
Shimada Yukiko
Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University
-
Murakami-Murofushi Kimiko
Department of Biology, Faculty of Science, Ochanomizu University
-
Shimada Yukiko
Depertment Of Biology Faculty Of Science Ochanomizu University
-
Shimada Yukiko
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
-
Nakano Mariko
Department of Electrical Engineering, Universidad Autonoma Metropolitana
-
Nakano Mariko
Department Of Biology Faculty Of Science Ochanomizu University
-
Murakami‐murofushi K
Department Of Biology Fscutry Of Science Ochanomizu University
-
Murakami-murofushi Kimiko
Department Of Biology Faculty Of Science Ochanomizu University
関連論文
- Deciphering cellular functions of protein phosphatases by comparison of gene expression profiles in Saccharomyces cerevisiae(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- RESPONSE OF A TRUE SLIME MOLD, Physarum polycephalum, TO SALT STRESS II : The Effects of The Inhibitors for RNA and Protein Syntheses on Stress-induced Microcyst Formation
- Characterization of Nuclear, and Nuclear Matrix-Bound DNA Polymerases of Normal Rat Liver
- Purification and Characterization of an Acid Protease from Myxoamoebae of a True Slime Mold, Physarum polycephalum
- Fatty Acid Species of Bio-Active Lysophosphatidic acid from Haploid Myxoamoebae of Physarum Polycephalum
- Extracellular Polysaccharide from a True Slime Mold, Physarum Polycephalum. Polymerization and Auto-Degradation Associated with Cell Growth, and Its Inhibitory Activity on Eukaryotic DNA Polymerase α
- Isolation of a New Species of Physarum Lysophatidic Acid, PHYLPA, and its Effect on DNA Polymerase Activity
- Steryl Glucoside is a Lipid Mediator in Stress-responsive Signal Transduction
- A Variable Step Size (VSS-CC) NLMS Algorithm
- A Novel 66-kDa Stress Protein,p66,Associated with the Process of Cyst Formation of Physarum polycephalum Is a Physarum Homologue of a Yeast Actin-Interacting Oritein,AIP1
- EXPRESSION OF TELOMERASE ACTIVITY ASSOCIATED WITH TRANSFORMATION OF HUMAN FIBROBLASTS
- TELOMERE AND TELOMERASE IN HUMAN LEUKOCYTES AND IMMORTAL CELL LINES
- Inhibition of Cell Proliferation by a Unique Lysophosphatidic Acid, PHYLPA, Isolated from Physarum polycephalum: Signaling Events of Antiproliferative Action by PHYLPA
- STIMULATION OF Gq PROTEIN-COUPLED SIGNAL TRANSDUCTION BY CYCLIC PHOSPHATIDIC ACID (cPA) AND ACTIVATION OF PROTEIN KINASE C IN VITRO
- Expression of a 66-kD Heat Shock Protein Associated with the Process of Cyst Formation of a True Slime Mold, Physarum polycephalum.
- Activation of a Ca^ -dependent Protein Kinase in Response to Heat Shock in the Myxoamoebae of a True Slime Mold, Physarum Polycephalum
- A Novel Purification Method of Sterols and Steryl Glucoside from Plasmodia of a True Slime Mold, Physarum Polycephalum
- RESPONSE OF A TRUE SLIME MOLD, Physarum polycephalum, TO SALT STRESS
- Biological Functions of a Novel Lipid Mediator, Cyclic Phosphatidic Acid (cPA)
- Examination of The Correlation between DNA-dependent Protein Kinase and Telomerase Activity
- Existence of poriferasterol monoglucoside and UDP-glucose: Poriferasterol glucosyltransferase in haploid myxoamoebae of mating-less mutant, Colonia strain, of Physarum polycephalum.