IMPAIRMENT OF ACTIVE AVOIDANCE RESPONSE IN RATS WITH CONTINUOUS INFUSION OF QUINOLINIC ACID INTO THE LATERAL VENTRICLE
スポンサーリンク
概要
- 論文の詳細を見る
Continuous infusion of quinolinic acid (QA) at low doses into the lateral ventricle has been previously shown to cause a reduction of the hippocampal and cortical ChAT activities in rats although GAD activities were unchanged. In the present study, we have studied behavioral changes in rats with continuous infusion of QA in an active avoidance task. Acquisition of active avoidance was significantly impaired in rats with QA infusion compared to control. These results suggest that continuous infusion of QA is a useful technique for the study of chronic neurodegenerative diseases associated with memory impairement.
- 公益社団法人日本薬学会の論文
著者
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YAMADA Kiyofumi
Department of Neurosurgery, Graduate School of Medicine, Gifu University
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Nabeshima Toshitaka
Department of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Meijo University, J
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Yamada Kiyofumi
Department Of Hospital Pharmacy Nagoya University School Of Medicine
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Nabeshima Toshitaka
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Nabeshima Toshitaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
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Yamada Kiyomi
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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KAMEYAMA TSUTOMU
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University
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Kameyama Tsutomu
Faculty Of Pharmaceutical Sciences Nagoya City University
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Kameyama Tsutomu
Department Of Biology Faculty Of Science Ochanomiz University
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Kameyama T
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
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Yamada Kiyofumi
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Nabeshima Toshitaka
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Kameyama Tsutomu
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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Kameyama Tsutomu
Dept. Of Chem. Pharmaco. Meijo Univ.
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Yamada Kiyofumi
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Nabeshima Toshitaka
Department Of Hospital Pharmacy School Of Medicine Nagoya University
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