Aged-Related Changes in Learning and Memory, Choline Acetyltransferase Activity and Number of Neuronal Cells in Rats
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概要
- 論文の詳細を見る
In a water maze task, the goal latency and distance of swimming onto the platform of aged rats (24 months old) were slowly shortened by repeated trainings compared with those of young rats (8 weeks old). A significant decrease in choline acetyltransferase activity in the frontal cortex, parietal cortex and striatum was observed in aged rats. Moreover, the number of neuronal cells in the hippocampal CAl subfield and dentate gyrus of aged rats was smaller than that of young rats. The atrophy of striatal cells was observed. These results suggest that age-related delay of acquisition is due to the above-mentioned biochemical and histological changes, and that rates of aging in biochemical and morphological parameters are different in the discrete brain areas.
- 公益社団法人日本薬学会の論文
著者
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Ogawa S
Nagoya Univ. Nagoya Jpn
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Ogawa Shinichi
Department Of Frontier Materials Graduate School Of Engineering Nagoya Institute Of Technology
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ISHIMARU Hirohisa
Department of Neuropsychopharmacology (Tsumura), Gunma University, School of Medicine
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Nabeshima Toshitaka
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Nabeshima Toshitaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
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Fukuta Taneo
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University School Of Medicine
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Kameyama Tsutomu
Faculty Of Pharmaceutical Sciences Nagoya City University
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Kameyama Tsutomu
Department Of Biology Faculty Of Science Ochanomiz University
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FUJI Kazuyuki
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University
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Kameyama T
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
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Ishimaru Hirohisa
Department Of Neuropsychopharmacology (tsumura) Gunma University School Of Medicine
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Nabeshima Toshitaka
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Kameyama Tsutomu
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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Kameyama Tsutomu
Dept. Of Chem. Pharmaco. Meijo Univ.
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Nabeshima Toshitaka
Department Of Hospital Pharmacy School Of Medicine Nagoya University
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