Amyloid Pathology and Protein Kinase C (PKC) : Possible Therapeutics Effects of PKC Activators
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概要
- 論文の詳細を見る
Amyloid β-protein (Aβ) is one of the most studied peptides in human neurodegenerative disorders. Although much has been learned about the biochemistry of this peptide, fundamental questions such as when and how the Aβ becomes pathologic remain unanswered. In this article we review the recent findings on the biology and pathology of Aβ and the role protein kinase C (PKC) plays in these processes. The potential neuroprotective role of PKC and the possible therapeutic effects of PKC activators in Alzheimer’s disease (AD) will be discussed. Briefly, comments will be also addressed on the role of PKC in cell death and neurogenesis in AD.
- 社団法人 日本薬理学会の論文
- 2005-01-20
著者
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Yamada Kiyofumi
Laboratory Of Experimental Therapeutics Department Of Clinical Pharmacy Faculty Of Pharmaceutical Sc
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Nabeshima Toshitaka
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Nabeshima Toshitaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
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Yamada Kiyomi
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Yamada Kiyofumi
Dept. Of Neuropsychopharmacol. & Hosp. Pharm. Nagoya U. Sch. Of Med.
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OLARIU Ana
Unit on Neuroplasticity, National Institute of Mental Health, National Institutes of Health
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Nabeshima Toshitaka
Dept. Of Neuropsychopharmacol. & Hosp. Pharm. Nagoya U. Sch. Of Med.
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Olariu Ana
Unit On Neuroplasticity National Institute Of Mental Health National Institutes Of Health
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Nabeshima Toshitaka
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Nabeshima Toshitaka
Department Of Hospital Pharmacy Nagoya University School Of Medicine
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Nabeshima Toshitaka
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
-
Nabeshima Toshitaka
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Yamada Kiyofumi
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Nabeshima Toshitaka
Department Of Hospital Pharmacy School Of Medicine Nagoya University
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