Tissue Plasminogen Activator Is Not Involved in Methamphetamine-Induced Neurotoxicity
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概要
- 論文の詳細を見る
To investigate the role of tissue plasminogen activator (tPA) in methamphetamine (METH)-induced dopaminergic neurotoxicity, we compared the changes in tyrosine hydroxylase (TH) and dopamine transporter (DAT) levels in the striatum after repetitive treatment of METH at 4 mg/kg among wild-type, tPA-deficient (tPA−/−), and protease activated receptor-1–deficient (PAR-1−/−) mice. METH treatment caused a marked decrease in TH and DAT levels in the striatum of those mice with a similar magnitude. No difference in METH-induced abnormal behavior and hyperthermia was observed among the three types of mice. These results suggest that neither tPA nor PAR-1 is involved in METH-induced dopaminergic neurotoxicity in vivo.
- 社団法人 日本薬理学会の論文
- 2008-02-20
著者
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YAMADA Kiyofumi
Laboratory of Neuropsychopharmacology, Division of Pharmaceutical Sciences, Graduate School of Natur
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Nabeshima Toshitaka
Department of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Meijo University, J
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Takuma Kazuhiro
Laboratory Of Neuropsychopharmacology Graduate School Of Natural Science And Technology Kanazawa Uni
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Yamada Kiyofumi
Laboratory Of Experimental Therapeutics Department Of Clinical Pharmacy Faculty Of Pharmaceutical Sc
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MIZOGUCHI Hiroyuki
Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science
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Takuma Kazuhiro
Laboratory Of Molecular Neuropharmacology Graduate School Of Pharmaceutical Sciences Osaka Universit
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Nabeshima Toshitaka
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Nabeshima Toshitaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
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Mizoguchi Hiroyuki
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Yamada Kiyomi
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Yamada Kiyofumi
Dept. Of Neuropsychopharmacol. & Hosp. Pharm. Nagoya U. Sch. Of Med.
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FUKAKUSA Ayumi
Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa U
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KOIKE Hiroyuki
Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa U
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Fukakusa Ayumi
Laboratory Of Neuropsychopharmacology Graduate School Of Natural Science And Technology Kanazawa Uni
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Nabeshima Toshitaka
Dept. Of Neuropsychopharmacol. & Hosp. Pharm. Nagoya U. Sch. Of Med.
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Koike Hiroyuki
Laboratory Of Neuropsychopharmacology Graduate School Of Natural Science And Technology Kanazawa Uni
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Nabeshima Toshitaka
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Nabeshima Toshitaka
Department Of Hospital Pharmacy Nagoya University School Of Medicine
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Nabeshima Toshitaka
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Takuma Kazuhiro
Laboratory Of Medicinal Pharmacology Graduate School Of Pharmaceutical Sciences Osaka University
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Nabeshima Toshitaka
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Yamada Kiyofumi
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Nabeshima Toshitaka
Department Of Hospital Pharmacy School Of Medicine Nagoya University
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