Recovery and Maintenance of Copper Levels in Geriatric Patients on Enteral Feeding for a Prolonged Period
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概要
- 論文の詳細を見る
Latent copper deficiency develops after 3 mo in patients receiving enteral feeding solutions with low copper levels. We examined whether a copper-rich enteral solution restores and maintains the level of copper in serum for a prolonged period. The study group consisted of 13 patients (eight males and five females). Commercial preparations, F2α^[○!R] and Lifelon-PZ^[○!R], for enteral administration were used. F2α^[○!R] and Lifelon-PZ^[○!R] contain 1.6 and 0.13mg/L, respectively, of copper. Serum copper levels were monitored in patients before and after administration of F2α^[○!R], a copper-rich enteral solution, at the neurological ward of Nagoya Daini Red Cross Hospital. Four of the 13 patients received Liflon-PZ^[○!R], a copper-poor enteral solution, before this trial. Blood samples were taken every month. The daily average copper dosage with F2α^[○!R] was 1.8±0.4mg/d (1.0-2.4mg/d). The copper level in the four patients who received Liflon-PZ^[○!R] was 10.5±5.5 μmol/L before this trial. The level rose to 18.9±3.6 μmol/L 1 mo after the change to the copper-rich, F2α^[○!R]. The average serum copper level in the other patients before the start of enteral feeding was 15.3±5.0 μmol/L. The proper copper level was maintained with F2α^[○!R] in the long term. A copper-rich enteral preparation could easily restore and maintain serum copper levels for a prolonged period. A dose of 1.8±0.4mg copper/d (1.0-2.4mg/d) was sufficient for our patients.
- 日本ビタミン学会の論文
著者
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Ito Yuki
Department Of Pharmacy Nagoya Daini Red Cross Hospital
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Ito Yuki
Department Of Biotechnology National Institute Of Agrobiological Resources Ministry Of Agriculture F
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Nabeshima Toshitaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
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Ando Tetsuo
Department Of Epidemiology And Preventive Medicine Kagoshima University Graduate School Of Medical A
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Ando Tetsuo
Department Of Neurology Anjo Kosei Hospital
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Nabeshima Toshitaka
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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