Effects of Risperidone on Phencyclidine-Induced Behaviors: Comparison with Haloperidol and Ritanserin.
スポンサーリンク
概要
- 論文の詳細を見る
In this study, we investigated whether risperidone, a serotonin-S<SUB>2A</SUB> (5-HT<SUB>2A</SUB>)/dopamine-D<SUB>2</SUB> (D<SUB>2</SUB>)-receptor antagonist, inhibits phencyclidine (PCP)-induced stereotyped behaviors in comparison with haloperidol and ritanserin. Moreover, we also attempted to investigate the effects of these antipsychotics on the contents of dopamine, serotonin (5-HT) and their metabolites in rat striatum and frontal cortex. In rats, PCP (5 mg/kg, i.p.) caused hyperlocomotion and stereotyped behaviors, including sniffing, head-weaving, backpedalling and turning. Both risperidone (0.8-2.4 mg/kg, p.o.) and haloperidol (0.3-1.0 mg/kg, p.o.) inhibited these behaviors, except for backpedalling, in a dose-dependent manner. PCP (10 mg/kg, i.p.) produced hyperlocomotion and stereotyped behaviors, including rearing, sniffing head-twitch, backpedalling and turning. Risperidone (0.8-2.4 mg/kg, p.o.) inhibited both hyperlocomotion and PCP-induced behaviors, except for backpedalling, while ritanserin (3-10 mg/kg, p.o.) inhibited only the head-twitch. These results suggest that risperidone may have an antipsychotic effect on schizophrenia as well as PCP psychosis in humans by exerting a mixed 5-HT<SUB>2A</SUB>/D<SUB>2</SUB> antagonism. Neurochemically, the increasing effects of risperidone on the content of DOPAC and the ratio of DOPAC to dopamine in the striatum were lower than those of haloperidol. These findings may support the view that the extrapyramidal side effects of risperidone are lower than those of haloperidol in clinical situations.
著者
-
Yamada Kiyofumi
Department Of Hospital Pharmacy Nagoya University School Of Medicine
-
Nabeshima Toshitaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
-
Kitaichi Kiyoyuki
Department Of Cardiology Nagoya University Graduate School Of Medicine
-
Furukawa Hiroshi
Department Of Applied Chemistry Faculty Of Engineering Nagasaki University
-
HASEGAWA Takaaki
Department of Bacteriology, Nagoya University School of Medicine
-
Kitaichi Kiyoyuki
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine
-
Furukawa Hiroshi
Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Meijo University
関連論文
- Growth Hormone-Releaser Diet Attenuates β-Amyloid(1-42)-Induced Cognitive Impairment via Stimulation of the Insulin-Like Growth Factor (IGF)-1 Receptor in Mice
- Parishin C Attenuates Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice: Involvements of 5-HT1A Receptor
- Convulsion During Intra-arterial Infusion of Fasudil Hydrochloride for the Treatment of Cerebral Vasospasm Following Subarachnoid Hemorrhage
- Detection of Gastric Cancer Micrometastases in Lymph Nodes by Amplification of Keratin 19 mRNA with Reverse Transcriptase-Polymerase Chain Reaction
- Altered Brain Penetration of Diclofenac and Mefenamic Acid, but Not Acetaminophen, in Shiga-Like Toxin II-Treated Mice
- Combined Resection of the Aorta for an Esophageal Carcinoma invading the Aorta Through a Right Transthoracic Approach
- Assessment of Plasma NO in Patients with Diabetes Mellitus(Atherosclerosis, Clinical 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Effects of Dietary Vegetable Oils on Behavior and Drug Responses in Mice
- Rhabdomyosarcoma Presenting as an Anterior Cervical Mass in an Adult : Report of a Case
- Effect of Y Substitution for the Ca Site in the 110 K Phase of (Bi, Pb)-Sr-Ca-Cu-O Superconductors
- 高カロリー輸液施行時の家兎における酸代謝に対する塩酸および酢酸の影響
- Multiple Inflammatory Pseudotumors Mimicking Liver Metastasis from Colon Cancer : Report of a Case
- Neuropsychotoxicity of Abused Drugs : Potential of Dextromethorphan and Novel Neuroprotective Analogs of Dextromethorphan With Improved Safety Profiles in Terms of Abuse and Neuroprotective Effects
- Exposure to Extremely Low Frequency Magnetic Fields Enhances Locomotor Activity via Activation of Dopamine D_1-Like Receptors
- Growth Hormone Releaser Attenuates β-Amyloid (1-42)-Induced Memory Impairment in Mice
- PAP 9704, a Korean Herbal Medicine Attenuates Methamphetamine-Induced Hyperlocomotion via Adenosine A_ Receptor Stimulation in Mice(Pharmacology)
- Aneurysms in the Ascending Aorta Adherent to the Sternum After Cardiac Surgery
- Surgical Repair of Postinfarction Ventricular Septal Rupture
- Saccular Descending Thoracic Aortic Aneurysm With Dysphagia
- Selective Phosphodiesterase Type 4 Inhibitors Reduce the Prolonged Survival of Eosinophils Stimulated by Granulocyte-Macrophage Colony-Stimulating Factor
- Induction of Histamine Release from Rat Peritoneal Mast Cells by Histatins
- Effect of Dietary Fiber on Morphine-induced Constipation in Rats(Food & Nutrition Science)
- Superficial Temporal Artery to Middle Cerebral Artery Double Bypass Via a Small Craniotomy : —Technical Note—
- EXPRESSIONS OF MULTIDRUG RESISTANCE-RELATED PROTEIN 1 IN THE RAT OLFACTORY EPITHELIUM(Physiology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- Evaluation of Interleukin-2 mRNA in Whole Blood as a Parameter for Monitoring Cyclosporine Pharmacodynamics(Pharmacology)
- Effects of Bacterial Endotoxin on Drug Pharmacokinetics
- Diffuse chronic leptomeningitis with seropositive rheumatoid arthritis : report of a case successfully treated as rheumatoid leptomeningitis
- Sentinel node biopsy versus elective lymph node dissection in patients with cutaneous melanoma in a Japanese population
- Angioplasty and Stenting of Totally Occluded Common Carotid Artery at the Chronic Stage : Case Report
- Late-Type Recurrence at the Port Site of Unexpected Gallbladder Carcinoma After a Laparoscopic Cholecystectomy : Report of a Case
- Structure-Related Pharmacokinetics of Xanthines after Direct Administration into the Peritoneal Cavity of Rats
- DESIGN OF A PHENCYCLIDINE IMPLANTATION PELLET : SUITABLE FOR TOLERANCE DEVELOPMENT
- MECHANISM OF TOLERANCE DEVELOPMENT TO PHENCYCLIDINE IN RELATION TO GABA-ERGIC NEURONAL AND DISPOSITIONAL FUNCTIONS IN MICE
- Molecular Mechanism of Cholinergic Dysfunction and Cognitive Deficits Induced by Amyloid β-Peptide
- Tissue Plasminogen Activator Is Not Involved in Methamphetamine-Induced Neurotoxicity
- Neuropsychotoxicity of Abused Drugs : Involvement of Matrix Metalloproteinase-2 and -9 and Tissue Inhibitor of Matrix Metalloproteinase-2 in Methamphetamine-Induced Behavioral Sensitization and Reward in Rodents
- Tissue Plasminogen Activator (t-PA) Is Involved in Morphine-Induced Rewarding Effects
- Superficial Temporal Artery to Middle Cerebral Artery Double Bypass Via a Small Craniotomy : Technical Note
- The role of N-methyl-D-aspartate receptors in development of morphine dependence in mice (NEREVOUS SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Comparative Absorption of 5-Aminosalicylic Acid(5-ASA)after Administration of a 5-ASA Enema and Salazosulfapyridine(SASP)after an SASP Suppository in Japanese Volunteers
- DOSE-DEPENDENT PHARMACOKINETICS OF ENPROFYLLINE IN RATS
- The Roles of Glial Cell Line-Derived Neurotrophic Factor, Tumor Necrosis Factor-α, and an Inducer of These Factors in Drug Dependence
- Prophylaxis of Local Vascular Graft Infection with Levofloxacin Incorporated into Albumin-Sealed Dacron Graft (LVFX-ALB Graft)
- Prevention of Vascular Graft Infection by Sisomicin Incorporated into Fibrin Glue
- Effects of Nicotine on Stress Response in Mice
- DEVELOPMENT OF AMNESIA MODEL FOR SCREENING OF NOOTROPIC DRUGS AND EFFECTS OF MEVALONIC-GABA ON LEARNING AND MEMORY IN MICE
- Reduction in the number of NADPH-diaphorase-positive cells in the cerebral cortex and striatum in aged rats
- S5-4 Psychobehavioral deficits induced by a non-competitive N-methyl-D-aspartate receptor antagonist and signal transduction through N-methyl-D-aspartate receptors(SYMPOSIUM 5: PHYSIOLOGY AND DISEASE OF GLUTAMATE IN NEURONAL AND GLIAL CELLS)(Proceedings o
- Elimination Kinetics of Quinaprilat and Perindoprilat in Hypertensive Patients with Renal Failure on Haemodialysis
- Conditioned Suppression of Motility : Possibility for Evaluation of Learning and Memory in Mice
- TOXICITY OF β-AMYLOID PEPTIDE
- The Pharmacokinetic Properties of Methamphetamine in Rats with Previous Repeated Exposure to Methamphetamine: The Differences between Long-Evans and Wistar Rats
- DOPAMINERGIC INVOLVEMENT IN PHENCYCLIDINE-INDUCED STEREOTYPED BEHAVIOR
- Perspectives of Pharmacotherapy in Alzheimer's Disease
- A survey of antipsychotic polypharmacy in outpatients at Nagoya University Hospital
- The Necessity of Adjusting the Dosage of Zonisamide When Coadministered with Other Anti-epileptic Drugs
- Parishin C Attenuates Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice : Involvements of 5-HT_ Receptor
- Basic and Translational Research on Proteinase-Activated Receptors : Regulation of Nicotine Reward by the Tissue Plasminogen Activator (tPA) : Plasmin System via Proteinase-Activated Receptor 1
- Drug Dependence, Synaptic Plasticity, and Tissue Plasminogen Activator
- Up-regulation of cAMP, but not voltage-sensitive calcium ion channels is involved in the inhibitory effects of nefiracetam on methamphetamine-induced discriminative responses
- IMPAIRMENT OF ACTIVE AVOIDANCE RESPONSE IN RATS WITH CONTINUOUS INFUSION OF QUINOLINIC ACID INTO THE LATERAL VENTRICLE
- Recovery and Maintenance of Copper Levels in Geriatric Patients on Enteral Feeding for a Prolonged Period
- EFFECTS OF CATECHOLAMINERGIC OR TRYPTAMINERGIC AGENTS ON THE MORPHINE-INDUCED STRAUB TAIL REACTION
- An Environmental and Biological Study of Occupational Exposure to Cyclophosphamide in the Pharmacy of a Japanese Community Hospital Designated for the Treatment of Cancer
- Aged-Related Changes in Learning and Memory, Choline Acetyltransferase Activity and Number of Neuronal Cells in Rats
- Amyloid Pathology and Protein Kinase C (PKC) : Possible Therapeutics Effects of PKC Activators
- Brain-Derived Neurotrophic Factor/TrkB Signaling in Memory Processes
- Endogenous Modulators for Drug Dependence
- CONDITIONED SUPPRESSION AND OPIOID KAPPA RECEPTOR IN MICE
- Neuropsychotoxic and Neuroprotective Potentials of Dextromethorphan and Its Analogs
- Role of Catecholaminergic and Cyclic AMP Systems in Psychological Dependence on Phencyclidine: A Study in Mutant Mice
- Skin Tests of a Novel Nicotine Patch, PHK-301p, in Healthy Male Volunteers : Phase I, Placebo-Controlled Study
- S9-2 Anti-addictive and pro-addictive substances commonly involved in methamphetamine and morphine dependence(SYMPOSIUM 9: MOLECULAR MECHANISMS OF DRUG DEPENDENCE)(Proceedings of the 31st Annual Meeting)
- PRO-ADDICTIVE AND ANTI-ADDICTIVE FACTORS FOR DRUG DEPENDENCE
- OTOTOXICITY INDUCED BY PRE-AND POSTNATAL EXPOSURE TO AMINOGLYCOSIDE ANTIBIOTICS
- NEUROTOXICITY OF CARBON MONOXIDE IN CENTRAL NERVOUS SYSTEM
- The High Atherosclerotic Risk Among Epileptics : the Atheroprotective Role of Multivitamins
- ROLE OF DOPAMINERGIC AND SEROTONERGIC NEURONAL SYSTEMS IN THE PREFRONTAL CORTEX OF RATS IN PHENCYCLIDINE-INDUCED BEHAVIORS
- ROLE OF DOPAMINERGIC AND GABAERGIC MECHANISMS IN DISCRETE BRAIN AREAS IN PHENCYCLIDINE-INDUCED LOCOMOTOR STIMULATION AND TURNING BEHAVIOR
- INVOLVEMENT OF OPIOID RECEPTORS IN HYPO- AND HYPER-THERMIC EFFECTS INDUCED BY PHENCYCLIDINE IN MICE
- EFFECTS OF DIFENAMIZOLE ON CONTENT OF CATECHOLAMINES AND METABOLITES IN MOUSE BRAIN
- Two pathways of nitric oxide production through glutamate receptors in the rat cerebellum in vivo
- CORRELATION BETWEEN THE 5-HYDROXYTRYPTAMINE CONTENTS IN THE BRAIN AND DEGREES OF SENSORY, AND LOCOMOTOR ACTIVITIES IN THE RAT
- Neuropsychotoxic and Neuroprotective Potentials of Dextromethorphan and Its Analogs
- Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by In Vitro Autoradiography (2): Changes in GABAA and Benzodiazepine Receptor Binding
- Vulnerability in Early Life to Changes in the Rearing Environment Plays a Crucial Role in the Aetiopathology of Psychiatric Disorders
- The Evaluation of Risk Factors Associated with Adverse Drug Reactions by Metformin in Type 2 Diabetes Mellitus
- D-Serine Ameliorates Neonatal PolyI:C Treatment–Induced Emotional and Cognitive Impairments in Adult Mice
- Reliability and Validity of the Japanese Version of BEMIB Modified for Patients With Bipolar Disorder: a Self-rating Scale for Medication Adherence
- Antitumor Activity of Two Novel Low Immunosuppressive Fluoropyrimidines UK-21 and UK-25.
- Effects of BMY-21502 on Anoxia in Mice.
- Animal Model for Schizophrenia That Reflects Gene-Environment Interactions
- Effects of Risperidone on Phencyclidine-Induced Behaviors: Comparison with Haloperidol and Ritanserin.
- Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by In Vitro Autoradiography (1): Changes in the (3H)QNB Binding.
- Neuropharmacological Characterization of Voltage-Sensitive Calcium Channels: Possible Existence of Neomycin-Sensitive, .OMEGA.-Conotoxin GVIA- and Dihydropyridines-Resistant Calcium Channels in the Rat Brain.
- Effects of Nerve Growth Factor(NGF) in Rats with Basal Forebrain Lesions.
- Anticancer Effects of Adriamycin-Loaded Hydroxyapatite Implants Determined in a Swarm Rat Chondrosarcoma Model.
- Antitumor Effects and Distribution of Adriamycin Incorporated into Hydroxyapatite Implants in a Cancer Rat Model Bearing Swarm Rat Chondrosarcoma.
- Characteristics of Transient Cerebral Ischemia-Induced Deficits on Various Learning and Memory Tasks in Male Mongolian Gerbils.
- D-Serine Ameliorates Neonatal PolyI:C Treatment-Induced Emotional and Cognitive Impairments in Adult Mice