Induction of Histamine Release from Rat Peritoneal Mast Cells by Histatins
スポンサーリンク
概要
- 論文の詳細を見る
Human salivary histatins (Hsts), which belong to a salivary polypeptide family, have potent antifungal activity against Candida albicans and Cryptococcus neoformans, and are expected to be useful as therapeutic reagents against Candida species. However, little is known about the effect of Hsts on host immune systems. Thus we conducted a series of in vitro experiments with rat mast cells to determine whether histatin 5 (Hst 5) or histatin 8 (Hst 8) has a histamine-releasing effect on mast cells. Both Hst 5 and Hst 8 induced histamine release from rat peritoneal mast cells in a dose-dependent manner (10^<-9> to 10^<-5>M). Hst 5 had a stronger releasing effect than Hst 8. The histamine release induced by Hst 5 (10^<-6>M) was increased by the presence of 0.5 mM Ca^<2+> but decreased by 2mM Ca^<2+>. Alternatively, the histamine release induced by Hst 8 (10^<-6>M) was inhibited by the presence of Ca^<2+> (0.5 to 2mM). These results suggest that Hsts have limited usefulness as therapeutic agents due to induction of histamine release from mast cells.
- 公益社団法人日本薬学会の論文
- 2001-11-01
著者
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Shibata Eiji
Department Of Health And Psychosocial Medicine Aichi Medical University
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Shibata E
中華人民共和国
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Shibata Eiji
Center For Microelectronic Systems Kyushu Institute Of Technology
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Shibata Eiji
Graduate School Of Kumamoto University
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Shibata Eiji
Department Of Health And Psychosocial Medicine Aichi Medical University School Of Medicine
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Shibata Eiji
Aichi Medical University
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Shibata Eiji
Department Of Medical Technology Faculty Of Health Sciences Nagoya University School Of Medicine
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TATSUMI Yasuaki
Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science and Technology, Kan
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Suzuki R
Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University
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TAKAGI Kenji
Department of Medical Technology, Nagoya University School of Health Sciences
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TAKAGI Kenzo
Department of Medical Technology, Nagoya University School of Health Sciences
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HASEGAWA Takaaki
Department of Pharmacy and Pharmacokinetics, Aichi Medical University School of Medicine
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Baba K
Faculty Of Phamacognosy Osaka University Of Pharmaceutical Sciences
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Kimura Tomoki
Second Department Of Internal Medicine And Laboratory Medicine Nagoya University School Of Medicine
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Baba Kenji
Third Department Of Medicine Aichi Medical School School Of Medicine
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KITAICHI Kiyoyuki
Department of Medical Technology, Nagoya University School of Health Sciences
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Suzuki R
Graduate School Of Pharmaceutical Sciences Nagoya City University
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Baba K
Division Of Pharmacognosy Osaka University Of Pharmaceutical Sciences
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SUZUKI Ryujiro
Second Department of Internal Medicine and Laboratory Medicine, Nagoya University School of Medicine
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YOSHIDA Mitsunobu
Second Department of Internal Medicine and Laboratory Medicine, Nagoya University School of Medicine
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MATSUSHIMA Miyoko
Department of Medical Technology, Nagoya University School of Health Sciences
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Tatsumi Yasuaki
Department Of Legal Medicine Kanazawa University School Of Medicine
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Tatsumi Yasuaki
Department Of Medical Technology Nagoya University School Of Health Sciences
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Hasegawa Takaaki
Department Of Pharmacy And Pharmacokinetics Aichi Medical University School Of Medicine
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Hasegawa Takaaki
Third Division Of The Research Laboratory For Development Of Medicine School Of Pharmacy Hokuriku Un
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Takagi Kenzo
Department Of Internal Medicine Nagoya University School Of Medicine
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Tatsumi Y
Department Of Medical Technology Nagoya University School Of Health Sciences
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Matsushima Miyoko
Department Of Medical Technology Nagoya University School Of Health Sciences
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Kitaichi Kiyoyuki
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Hasegawa Takaaki
Department Of Hospital Pharmacy Nagoya University School Of Medicine
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Yoshida M
Second Department Of Internal Medicine And Laboratory Medicine Nagoya University School Of Medicine
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Takagi Kenji
Department Of Cardiology Nagoya University Graduate School Of Medicine
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HASEGAWA Takaaki
Department of Bacteriology, Nagoya University School of Medicine
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