Synthesis of a Biologically Active Fluorescent Derivative of GM1,a Main Ginseng Saponin Metabolite Formed by Intestinal Bacteria
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概要
- 論文の詳細を見る
A fluorescent derivative of GM1 [20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol], a main Ginseng saponin metabolite formed by intestinal bacteria, was obtained from the condensation of its trisnor-aldehyde derivative with dansyl hydrazine. The dansylated GM1 fluoresced strongly and showed almost the same properties as its parent compound in lipophilicity and biological activities, so this fluorescent compound might provide an insight into the mechanism of pharmacological activities of GM1.
- 公益社団法人日本薬学会の論文
- 1998-05-15
著者
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Murata J
Department Of Physiology Institute Of Health Sciences Hiroshima University Faculty Of Medicine
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TEZUKA Yasuhiro
Department of Natural Products Chemistry, Institute of Natural Medicine,Toyama Medical and Pharmaceu
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Kadota Shigetoshi
Department of Natural Products Chemistry, Institute of Natural Medicine, Toyama Medical and Pharmace
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SAIKI Ikuo
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceuti
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Saiki Ikuo
富山大学 薬学研究科応用薬理学
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HASEGAWA Hideo
Itto Institute of Life Science Research, Happy World, Inc.
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SUZUKI Ryuichi
Itto Institute of Life Science Research, Happy World, Inc.
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SAIKI Ikuo
Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama
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Kadota S
Institute Of Natural Medicine University Of Toyama
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Suzuki R
Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University
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Murata Jun
Department Of Physiology Institute Of Health Sciences Hiroshima University Faculty Of Medicine
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Murata Jun
Department Of Pathogenic Biochemistry
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Hasegawa Hideo
神戸薬科大学
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Suzuki R
Graduate School Of Pharmaceutical Sciences Nagoya City University
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Tezuka Yasuhiro
Department Of Natural Products Chemistry Institute Of Natural Medicine Toyama Medical And Pharmaceut
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Hasegawa Hideo
Itto Institute Of Life Science Research Happy World Inc.
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HASEGAWA Hideo
富山医科薬科大学和漢薬研究所病態生化学部門
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WAKABAYASHI Chisato
Department of Pathogenic Biochemistry
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Murata Jun
Department Of Applied Physics Faculty Of Engineering University Of Tokyo:presently At Musashi Works
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Hasegawa H
Oita Univ. Oita Jpn
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Saiki Ikuo
Department Of Pathogenic Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceutica
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Hasegawa Hideo
Itto Institute Of Life Science Research Happy World Inc
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Tezuka Yasuhiro
Department Of General Thoracic Surgery Jichi Medical University And Saitama Medical Center
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Saiki Ikuo
Department Of Bioscience Institute Of Natural Medicine Toyama University
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Wakabayashi Chisato
Department Of Metallurgy And Ceramics Science Graduate School Of Science And Engineering Tokyo Institute Of Technology
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Hasegawa Hideo
Itto Institute of Life Science Research, Happy World Inc.,
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門田 重利
Institute of Natural Medicine, University of Toyama
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WAKABAYASHI Chisato
Department of Metallurgy & Ceramics Science, Tokyo Institute of Technology
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