Constituents of the Vietnamese Medicinal Plant Orthosiphon stamineus
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概要
- 論文の詳細を見る
From the MeOH extract of the aerial part of Vietnamese Orthosiphon stamineus, five new isopimarane-type diterpenes [orthosiphols F-J (1-5)] and two new diterpenes [staminols A (6) and B (7)] with a novel carbon-framework, to which we proposed the name "staminane", and three new highly-oxygenated staminane-type diterpenes [staminolactones A (8) and B (9) and norstaminol A (10)] were isolated. Moreover, staminolactone A (8) is 8,14-secostaminane-type and staminolactone B (9) is 13,14-secostaminane-type, while norstaminol A (10) is 14-norstaminen-type. Together with these new diterpenes, sixteen known compounds were also isolated and identified to be : 7,3', 4'-tri-O-methylluteolin (11), eupatorin (12), sinensetin (13), 5-hydroxy-6,7,3'4'-tetramethoxyflavone (14), salvigenin (15), ladanein (16), tetramethylscutellarein (17), 6-hydroxy-5,7,4'-trimethoxyflavone (18), vomifoliol (19), aurantiamide acetate (20), rosmarinic acid (21), caffeic acid (22), oleanolic acid (23), ursolic acid (24), betulinic acid (25), and β-sitosterol (26). All the isolated compounds were tested for their cytotoxicity towards highly liver metastatic murine colon 26-L5 carcinoma cells, and the new diterpenes, except for 4,and flavonoids (11,12,16,18) showed cytotoxicity with an ED_^<50> value between 10 and 90 μg/ml.
- 社団法人日本薬学会の論文
- 2000-11-01
著者
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AWALE Suresh
Institute of Natural Medicine, University of Toyama
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KADOTA Shigetoshi
Institute of Natural Medicine, University of Toyama
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TEZUKA Yasuhiro
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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Awale Suresh
インドネシア
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Awale Suresh
富山大学和漢医薬学総合研究所
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Awale Suresh
Institute Of National Medicine Toyama Medical And Pharmaceutical University
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KALAUNI Surya
Institute of Natural Medicine, University of Toyama
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SAIKI Ikuo
Institute of Natural Medicine, University of Toyama
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BANSKOTA Arjun
Institute of Natural Medicine, University of Toyama
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KAWAKAMI Tsukasa
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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STAMPOULIS Pavlos
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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TRAN Kim
National University Ho Chi Minh City
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Banskota A
Institute Of Natural Medicine University Of Toyama
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Banskota Arjun
富山医科薬科大学和漢薬研究所
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Banskota Arjun
Institute Of National Medicine Toyama Medical And Pharmaceutical University
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Saiki Ikuo
富山大学 薬学研究科応用薬理学
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Saiki I
Division Of Pathogenic Biochemistry Institute Of Natural Medicine University Of Toyama
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SAIKI Ikuo
Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama
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Kadota S
Institute Of Natural Medicine University Of Toyama
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Tominaga Kazunari
Department Of Gastroenterology Osaka City University Graduate School Of Medicine
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Saiki Ikuo
Division Of Pathogenic Biochemistry Institute Of Natural Medicine University Of Toyama
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Awale Suresh
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Tran Kim
National University Hochiminh City
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Tominaga K
Osaka City Univ. Osaka Jpn
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Saiki Ikuo
Department Of Pathological Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceuti
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Tezuka Yasuhiro
Institute Of Natural Medicine Univeristy Of Toyama
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Torii K
Department Of Nuclear Medicine Graduate School Of Medicine Osaka City University
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Saiki Ikuo
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Kadota Shigetoshi
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Kalauni S
Institute Of Natural Medicine University Of Toyama
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Kawakami Tsukasa
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Saiki Ikuo
Institute Of Immunological Science Hokkaido University
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Banskota Arjun
Institute For Marine Biosciences National Research Council
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Stampoulis Pavlos
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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門田 重利
Institute of Natural Medicine, University of Toyama
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