Antiosteoporotic Activity of the Water Extract of Dioscorea spongiosa (Pharmacognosy)
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概要
- 論文の詳細を見る
After 60 MeOH and water extracts of natural crude drugs were screened for their ability to stimulate osteoblast proliferation, four MeOH extracts (Cynomorium songaricum, Drynaria fortunei, Lycium chinense, Rehmannia glutinosa) and seven water extracts (Cornus officinalis, Dendrobium nobile, Dioscorea spongiosa, Drynaria fortunei, Eucommia ulmoides, Lycium chinensis, Viscum coloratum) showed that potent activities were evaluated for inhibition of osteoclast formation. The results indicated that the water extract of D. spongiosa not only showed the strongest stimulation of osteoblast proliferation but also possessed potent inhibitory activity aganist osteoclast formation, whereas it showed lower cytotoxicity in osteoblast and bone marrow cells. A further in vivo experiment determined the antiosteoporotic activity of this extract, in which it inhibited the decrease in cancellous bone mineral content, cancellous bone mineral density, and cortical bone mineral content of the proximal tibia in ovariectomized rats.
- 公益社団法人日本薬学会の論文
- 2004-04-01
著者
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TRAN Quan
National University-Hochiminh City, Hochiminh City
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KADOTA Shigetoshi
Institute of Natural Medicine, University of Toyama
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TEZUKA Yasuhiro
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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TRAN Quan
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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Kadota S
富山大学和漢医薬学総合研究所
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門田 重利
富山医科薬科大学和漢薬研究所化学応用部門
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門田 重利
富山大学和漢医薬学総合研究所資源開発部門化学応用分野
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KALAUNI Surya
Institute of Natural Medicine, University of Toyama
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Tran Quan
National University-hochiminh City Hochiminh City
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Kadota Shigetoshi
Institute Of Natural Medicine University Of Toyama
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Kadota Shigetoshi
富山大学和漢医薬学総合研究所 化学応用分野
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Kadota S
Institute Of Natural Medicine University Of Toyama
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Kadota Shigetoshi
Univ. Toyama Toyama Jpn
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Kadota Shigetoshi
インドネシア
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Tran Quan
National University
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MIYAHARA Tatsuro
Faculty of Medicine, University of Toyama
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Tran Q
National University - Hochiminh City
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Tran Quan
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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KOUDA Kyoji
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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門田 重利
Institute Of Natural Medicine University Of Toyama
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Yin Jun
Jilin Architectural and Civil Engineering Institute
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Tezuka Yasuhiro
Institute Of Natural Medicine Univeristy Of Toyama
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Miyahara T
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Miyahara Tatsuro
Faculty Of Medicine University Of Toyama
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YIN Jun
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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CHEN Yingjie
Shenyang Pharmaceutical University
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Komatsu K
Institute Of Natural Medicine. Toyama Medical And Pharmaceutical University
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Kadota Shigetoshi
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Kalauni S
Institute Of Natural Medicine University Of Toyama
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Kadota S
Toyama Medical And Pharamaceutical Univ. Toyama Jpn
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Yin Jun
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Kouda Kyoji
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Kouda K
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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手塚 康弘
Institute Of Natural Medicine University Of Toyama
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門田 重利
Institute of Natural Medicine, University of Toyama
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