Comparative Study of Seventeen Salvia Plants : Aldose Reductase Inhibitory Activity of Water and MeOH Extracts and Liquid Chromatography-Mass Spectrometry (LC-MS) Analysis of Water Extracts
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概要
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The dry root and rhizome of Salvia miltiorhiza (Lamiaceae) are used as a crude drug Danshen, while those of S. deserta (Xinjiang-Danshen) are mixed in Danshen at Xinjiang province when the former is in short supply. The water and MeOH extracts of S. deserta showed strong aldose reductase (AR) inhibitory activity, and their active constituents were determined to be polar compounds different from "tanshinones" of S. miltiorhiza, i.e., lithospermic acid B (1), salvianolic acid K (2), salviaflaside (3), and rosmarinic acid (4) (IC_<50>, 2.63-3.91μM).We also examined the AR inhibitory activity of water and MeOH extracts of seventeen Salvia plants, including ten species of Danshen resources (S. bowleyana, S. deserta, S. miltiorhiza, S. miltiorhiza var. miltiorhiza f. alba, S. paramiltiorhiza, S. paramiltiorhiza f. purpureo-rubra, S. przewalskii, S. przewalskii var. mandarinorum, S. sinica f. purpurea, S. trijuga), and their water extracts were also analyzed by liquid chromatography-mass spectrometry (LC-MS). The results indicated that there were four types with regard to the AR inhibitory activity and three types with regard to the amount of 1. Ten species used as Danshen resources showed good correlation between the AR inhibitory activity and the morphological classification. However, the intensities of their AR inhibitory activity varied, and they contained 1 in varying amounts. These facts suggested that the ten species were not the same, and thus their use as a Danshen resource should be based on their activity and/or active constituents.
- 公益社団法人日本薬学会の論文
- 1998-03-15
著者
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Kadota S
富山大学和漢医薬学総合研究所
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KAWAKAMI Tsukasa
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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TANAKA Ken
National Police Agency
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Kadota S
Institute Of Natural Medicine University Of Toyama
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Tominaga Kazunari
Department Of Gastroenterology Osaka City University Graduate School Of Medicine
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TEZUKA Yasuhiro
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University
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Namba Ttuneo
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Namba Tsuneo
富山医科薬科大学 生薬
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Namba Tsuneo
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Nagaoka Takema
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Nagaoka Takema
富山医科薬科大学和漢薬研究所
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Li J
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Basnet Purusotam
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Tran Kim
National University Hochiminh City
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Tominaga K
Osaka City Univ. Osaka Jpn
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Tezuka Yasuhiro
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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Torii K
Department Of Nuclear Medicine Graduate School Of Medicine Osaka City University
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KADOTA Shigetoshi
Research Institute of Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceu
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KASIMU Rena
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmace
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GONG Zhu-Nan
Department of Medicinal Botany, China Pharmaceutical University
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LI Jian-Xin
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmace
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Basnet Purusotam
富山医科薬科大学和漢薬研究所
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Basnet Purusotam
Research Center For Ethnomedicines Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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Kadota Shigetoshi
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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Li Jianxin
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Kawakami Tsukasa
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Kasimu Rena
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Gong Zhu-nan
Department Of Medicinal Botany China Pharmaceutical University
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Basnet P
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Li Jianxin
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Namba Tsuneo
Research Institute For Wakan-yaku (traditional Sino-japanese Medicine) Toyama Medical And Pharmaceut
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Namba Tsuneo
Research Institute For Wakan-yaku (oriental Medicine) Toyama Medical And Pharmaceutical University
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門田 重利
Institute of Natural Medicine, University of Toyama
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