Antiosteoporotic Activity of the Stems of Sambucus sieboldiana
スポンサーリンク
概要
- 論文の詳細を見る
We previously found that a methanolic extract of the stems of Sambucus sieboldiana inhibited bone resorption in organ culture. In this study, we further fractionated the methanol extract guided by the activity towards bone resorption stimulated by parathyroid hormone (PTH) in vitro. The ethyl acetate fraction (EtOAc Fr.) of the methanolic extract inhibited PTH-stimulated bone resorption of neonatal mouse bones, and the inhibitory activity was more potent than those of other fractions. Oral administration of the EtOAc Fr. (50 and 100 mg/kg/d) to ovariectomized (OVX) rat prevented the decrease in bone mineral density (BMD) of the lumbar (L_<2-4>) vertebra, indicating that the EtOAc Fr. is effective in vivo. Furthermore, the EtOAc Fr. (50,100 and 150 mg/kg/d) decreased the serum calcium level elevated in low calcium dietary rats. The phenolic constituents of the EtOAc fraction were examined for their inhibitory effect on bone resorption stimulated by PTH in neonatal mouse bone. Among them, vanillic acid, vanillin and coniferyl alcohol showed significant inhibitory effects on bone resorption. Of the compounds examined, vanillic acid was found to have a significant inhibitory effect on the decrease of BMD in OVX mice. Therefore, the EtOAc Fr. of S. sieboldiana showed a suppressive effect on bone resorption in vitro and in vivo. In addition, the inhibitory effects of the EtOAc Fr. on bone resorption may be at least partly due to the inhibitory action of vanillic acid.
- 社団法人日本薬学会の論文
- 1998-06-15
著者
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Seto Hikaru
Faculty Of Medicine Toyama Medical And Pharmaceutical University
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Seto Hikaru
富山医科薬科大学和漢薬研究所
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PRASAIN Jeevan
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmace
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Kadota S
Institute Of Natural Medicine University Of Toyama
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TEZUKA Yasuhiro
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University
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Namba Ttuneo
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Namba Tsuneo
富山医科薬科大学 生薬
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Namba Tsuneo
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Nagaoka Takema
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Nagaoka Takema
富山医科薬科大学和漢薬研究所
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Li J
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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MIYAHARA Tatsuro
Faculty of Medicine, University of Toyama
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Prasain Jeevan
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Tezuka Yasuhiro
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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Miyahara T
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Miyahara Tatsuro
Faculty Of Medicine University Of Toyama
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LI Huiying
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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TONAMI Syuichi
Faculty of Medicine, Toyama Medical and Pharmaceutical University
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LI Huiying
Research Institute of Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceu
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KADOTA Shigetoshi
Research Institute of Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceu
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LI Jianxin
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines)
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TADA Takahiro
Toyama Medical and Pharmaceutical University
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Kadota Shigetoshi
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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Li Jianxin
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Li Huiying
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Tada Takahiro
Research & Development Department Mikimoto Pharmaceutical Co. Ltd.
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Takamura Shuichi
Faculty Of Medicine Toyama Medical And Pharmaceutical University
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Takamura S
Graduate School Of Engineering Nagoya University
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Tonami Syuichi
Faculty Of Medicine Toyama Medical And Pharmaceutical University
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Li Jianxin
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Namba Tsuneo
Research Institute For Wakan-yaku (traditional Sino-japanese Medicine) Toyama Medical And Pharmaceut
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Prasain Jeevan
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Namba Tsuneo
Research Institute For Wakan-yaku (oriental Medicine) Toyama Medical And Pharmaceutical University
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門田 重利
Institute of Natural Medicine, University of Toyama
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