Inhibitory Mechanisms of Glycoprotein Fraction Derived from Miscanthus sinensis for the Immediate Phase Response of an IgE-Mediated Cutaneous Reaction

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概要

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• We investigated the inhibitory effect of the glycoprotein fraction (fraction 2) extracted from Miscanthus sinensis ANDERSSON (M. sinensis) on biphasic cutaneous reactions in mice passively sensitized with IgE. Biphasic skin reactions with peak responses at 1 (IPR, immediate phase reaction) and 24 h (LPR, late phase reaction) were caused by passive sensitization with an anti-dinitrophenol IgE monoclonal antibody (anti-DNP IgE mAb) followed by an epicutaneous challenge of 0.1% dinitrofluorobenzene (DNFB) in 100% ethanol. Intraperitoneal injection of fraction 2 before the DNFB challenge significantly inhibited the biphasic ear swelling response in passively sensitized mice in a dose-dependent manner (1-30 mg/kg). We also found that fraction 2 was effective at inhibiting the vascular permeability in mouse ear induced by an injection of compound 48/80,histamine or serotonin. In addition, fraction 2 inhibited scratching behavior as weel as ear edema observed within 2 h after DNFB challenge. Marked inhibition was observed in both passively sensitized and non-sensitized mice. The locomotor activity of mice was also reduced by the administration of fraction 2 as well as by diphenhydramine. These results suggest that the inhibitory effect of glycoprotein fraction 2 of M. sinesis on an IgE-mediated allergic inflammatory reaction is due to the protection of mediator-induced vascular permeability and that in addition to the inhibition of an inflammatory reaction, a sedative action is responsible for the inhibition of allergy-induced scaratching responses.

• 社団法人日本薬学会の論文
• 1999-01-15

著者

• KALAUNI Surya

  Institute of Natural Medicine, University of Toyama

• ANDOH Tsugunobu

  Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers

• KURAISHI Yasushi

  Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers

• NAGAI Hiroichi

  Department of Pharmacology, Gifu Pharmaceutical University

• SAIKI Ikuo

  Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceuti

• Saiki Ikuo

  富山大学 薬学研究科応用薬理学

• TAHARA Eiichi

  Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceuti

• SATOH Taku

  Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceuti

• WATANABE Chie

  Department of Pathogenic Biochemistry Research Institute for Wakan-Yaku

• MURAKAMI Koji

  Department of Pathogenic Biochemistry Research Institute for Wakan-Yaku

• HAYASHI Kazuko

  Department of Pathogenic Biochemistry Research Institute for Wakan-Yaku

• HASE Koji

  Natural Product Chemistry, Research Institute for Wakan-Yaku

• KADOTA Shigetoshi

  Natural Product Chemistry, Research Institute for Wakan-Yaku

• Andoh Tsugunobu

  Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit

• SAIKI Ikuo

  Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama

• Kuraishi Yasushi

  Department Of Applied Pharmacology Graduate School Of Medical And Pharmaceutical Science University

• Satoh Taku

  富山医科薬科大学和漢薬研究所

• Satoh Taku

  Department Of Applied And Bioapplied Chemistry Graduate School Of Engineering Osaka City University

• Kadota S

  Institute Of Natural Medicine University Of Toyama

• Hase Koji

  富山医科薬科大学和漢薬研究所

• Watanabe Chie

  Department Of Molecular Immunology Research Institute For Microbial Diseases And Crest Program Of Js

• Hase Koji

  Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu

• Murakami Koji

  Toyama Medical And Pharmaceutical Univ. Toyama

• Andoh Tsugunobu

  Department Of Applied Pharmacology Faculty Of Pharmaceu Tical Sciences

• Nagai Hiroichi

  Department Of Clinical Pharmacology Gifu Pharmaceutical University

• Tahara Eiichi

  Department Of Japanese Oriental (kampo) Medicine Faculty Of Medicine Toyama Medical And Pharmaceutic

• Murakami Koji

  Department Of General Medicine Omiya Medical Center Jichi Medical School

• Kuraishi Yasushi

  Department Of Applied Pharmacology Faculty Of Pharmaceu Tical Sciences

• Saiki Ikuo

  Department Of Pathogenic Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceutica

• Kuraishi Yasushi

  Department Of Applide Biochemistry Research Institute For Wakan-yaku Toyama Toyama Medical And Pharm

• Hase Koji

  Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu

• Saiki Ikuo

  Department Of Bioscience Institute Of Natural Medicine Toyama University

• Murakami Koji

  Department Of Food Science And Technology Faculty Of Agriculture Kyoto University

• Murakami Koji

  Department Of Civil And Structural Engineering Graduate School Of Engineering Kyushu University

• Andoh Tsugunobu

  Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit

• Watanabe Chie

  Department Of Medical Oncology Cancer Institute Hospital Japanese Foundation For Cancer Research

• Nagai Hiroichi

  Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama

• Tahara Eiichi

  Department of Japanese Oriental Medicine, Institute of Traditional Medicine, Kinki University

• 門田 重利

  Institute of Natural Medicine, University of Toyama

• HAYASHI Kazuko

  Department of Agricultural Chemistry, Faculty of Agriculture, Hokkaido University

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