Effects of Topical Application of Tacrolimus on Acute Itch-Associated Responses in Mice(Pharmacology)
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概要
- 論文の詳細を見る
Using mice, we examined whether the topical application of tacrolimus would produce an acute anti-pruritic effect. An itch-related response, scratching, was elicited by intradermal injections of mosquito allergen (10 μg/site) in sensitized mice and SLIGRL-NH_2 (protease-activated receptor-2 agonist, 50 nmol/site), histamine (100 nmol/site), serotonin (100 nmol/site) and substance P (100 nmol/site) in naive ones. Topical application of 1%, but neither 0.1% nor 0.3%, tacrolimus to the skin 1 h before injection inhibited scratching induced by mosquito allergen and SLIGRL-NH_2, without effects on scratching induced by histamine, serotonin, and substance P. Topical tacrolimus also inhibited licking induced by an intraplantar injection of capsaicin (0.1 μg/site). These results suggest that topical tacrolimus exerts acute inhibitory effects on allergic and protease-activated receptor-2-mediated itching. Though precise mechanisms remain unclear, the action on sensory neurons expressing protease-activated receptor-2 and transient receptor potential vanilloid-1 capsaicin receptor may be involved in the inhibitory effects of tacrolimus.
- 公益社団法人日本薬学会の論文
- 2008-04-01
著者
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Lee Jung-bum
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical Uni
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Lee Jung-bum
Department Of Pharmacognosy Graduate School Of Medical And Pharmaceutical Science University Of Toya
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Lee Jung-bum
富山医科薬科大学 薬学部
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Lee Jung-bum
富山大学 医学薬学研究部応用薬理学
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ANDOH Tsugunobu
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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KURAISHI Yasushi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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Andoh Tsugunobu
富山大学 医学薬学研究部応用薬理学
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Andoh Tsugunobu
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Kuraishi Yasushi
Department Of Applied Pharmacology Graduate School Of Medical And Pharmaceutical Science University
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Kuraishi Yasushi
富山大学 医学薬学研究部応用薬理学
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Kuraishi Yasushi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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NAKANO Tasuku
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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Nakano Tasuku
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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TAYAMA Manabu
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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KOSAKA Mayumi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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Andoh Tsugunobu
Department Of Applied Pharmacology Faculty Of Pharmaceu Tical Sciences
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Tayama Manabu
Dep. Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Univ. Of Toyama
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Kosaka Mayumi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Kuraishi Yasushi
Department Of Applied Pharmacology Faculty Of Pharmaceu Tical Sciences
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Kuraishi Yasushi
Department Of Applide Biochemistry Research Institute For Wakan-yaku Toyama Toyama Medical And Pharm
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Andoh Tsugunobu
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Tayama Manabu
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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