Evidence for Separate Involvement of Different μ-Opioid Receptor Subtypes in Itch and Analgesia Induced by Supraspinal Action of Opioids
スポンサーリンク
概要
- 論文の詳細を見る
The common adverse effect of centrally-injected μ-opioid receptor (μ-OR) agonists is pruritus. This study was conducted using mice to examine whether different subtypes of μ-OR would be responsible for pruritus and analgesia. Intracisternal injections of morphine and morphine-6β-glucronide (M6G), but not M3G, produced an antinociceptive effect. Morphine, but neither M6G nor M3G, induced facial scratching, a pruritus-related response. Facial scratching following morphine was not affected by the μ1-OR antagonist naloxonazine at doses that inhibited the antinociceptive effects. The results suggest that different subtype and/or splice variants of μ-OR are separately involved in pruritus and antinociception of opioids.
- 社団法人 日本薬理学会の論文
- 2008-04-20
著者
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永井 博弌
Department Of Pharmacology School Of Pharmaceutical Sciences Ohu University
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ANDOH Tsugunobu
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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NOJIMA Hiroshi
Department of Pharmacology, School of Pharmaceutical Sciences, Ohu University
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TAKAHATA Hiroki
Department of Pharmaceutical Chemistry, Tohoku Pharmaceutical University
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KURAISHI Yasushi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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YAGETA Yuichi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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KONNO Mitsuhiro
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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永井 博弌
岐阜薬科大学
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Nagai Hiroichi
富山医科薬科大学和漢薬研究所
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Nii Hiroaki
岐阜薬科大学 薬理学
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Andoh Tsugunobu
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Kuraishi Yasushi
Department Of Applied Pharmacology Graduate School Of Medical And Pharmaceutical Science University
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Kuraishi Yasushi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Nojima H
Department Of Pharmacology School Of Pharmaceutical Sciences Ohu University
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YAMAGUCHI MIYAMOTO
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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NEMOTO Hideo
Laboratory of Medical Chemistry, Graduate School of Medicine and Pharmaceutical Sciences, University
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Nagai Hiroichi
岐阜薬科大学 薬理
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Nojima Hiroshi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Nemoto Hideo
Laboratory Of Medical Chemistry Graduate School Of Medicine And Pharmaceutical Sciences University O
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Nemoto H
Osaka City Univ. Osaka Jpn
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Yageta Yuichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Andoh Tsugunobu
Department Of Applied Pharmacology Faculty Of Pharmaceu Tical Sciences
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Nagai Hiroichi
Department Of Pharmacology School Of Pharmaceutical Sciences Ohu University
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Nojima Hiroshi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Ohu University
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Takahata Hiroki
Department Of Pharmaceutical Chemistry Tohoku Pharmaceutical University
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Takahata Hiroki
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Yamaguchi Miyamoto
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Nojima Hiroshi
Faculty Of Horticulture Chiba University
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Nojima Hiroshi
Department Of Molecular Generics Research Institute For Microbial Diseases Osaka University
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Nojima H
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Kuraishi Yasushi
Department Of Applied Pharmacology Faculty Of Pharmaceu Tical Sciences
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Kuraishi Yasushi
Department Of Applide Biochemistry Research Institute For Wakan-yaku Toyama Toyama Medical And Pharm
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Nojima Hiroshi
Laboratory Of Medical Chemistry Graduate School Of Medicine And Pharmaceutical Sciences University O
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Nemoto Hideo
Laboratory Of Medical Chemistry Graduate School Of Medicine And Pharmaceutical Sciences University O
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Andoh Tsugunobu
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Takahata Hiroki
Department of Organochemical Design and Synthesis,Faculty of Pharmaceutical Sciences,Toyama Medical and Pharmaceutical University,2630 Sugitani,Toyama 930-0194,Japan
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Konno Mitsuhiro
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
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