Pharmacological Modulation of Antigen-Induced Airway Hyperresponsiveness by Thromboxane A_2 Inhibitors in Guinea Pigs

概要

論文の詳細を見る
The effects of OKY-046 (thromboxane A_2 (TXA_2) synthetase inhibitor) and ONO-3708 (TXA_2 receptor antagonist) on antigen-induced airway hyperreactivity in guinea pigs were investigated. Ketotifen was used as a reference drug. Seven inhalations of an antigen into actively sensitized animals resulted in an increase in airway reactivity to acetylcholine. Twenty-four hours after the final inhalation, the number of leukocytes (macrophages, neutrophils, eosinophils and lymphocytes) and the quantity of mediators (thromboxane B_2,leukotriene D_4 and histamine) in bronchoalveolar lavage fluid increased.All examined drugs inhibited the antigen-induced airway hyperreactivity to acetylcholine. Whereas ketotifen inhibited an accumulation of inflammatory cells (eosinophils and neutrophils) in bronchoalveolar lavage fluid, OKY-046 and ONO-3708 had no effect on the accumulation of inflammatory cells. OKY-046,but not ketotifen and ONO-3708,inhibited an increase of thromboxane B_2 in the bronchoalveolar lavage fluid after antigen provocation.These results suggest the participation of TXA_2 in the onset of antigen-induced airway hyperresponsiveness in guinea pigs, and the efficacy of TXA_2 inhibitors, without affecting the accumulation of inflammatory cells in bronchoalveolar lavage fluid.
公益社団法人日本薬学会の論文
1993-11-15