Intracisternal, But Not Intrathecal, Injection of Naloxone Inhibits Cutaneous Itch-Related Response in Mice(Pharmacology)

概要

論文の詳細を見る
The present study was conducted to determine whether cutaneous itch involves mu-opioid receptors in either of the spinal cord or lower brainstem or in both regions in mice. An intraplantar injection of serotonin hydrochloride (100nmol/site) induced biting, an itch-related behavior. The behavior was inhibited by subcutaneous (0.3-1mg/kg) and intracisternal (1-10nmol/site), but not intrathecal (1-10nmol/site), injections of naloxone hydrochloride. An intradermal injection of serotonin (100nmol/site) to the rostral back induced scratching, an itch-related behavior, which was inhibited by subcutaneous (1mg/kg) and intracisternal (10nmol/site) injections of naloxone. These results suggest that mu-opioid receptor in the lower brainstem, but not spinal cord, is a site of central pruritogenic action of opioids and is involved in the facilitatory regulation of itch signaling.
社団法人日本薬学会の論文
2008-11-01