Repeated Treatment With the Traditional Medicine Unsei-in Inhibits Substance P-Induced Itch-Associated Responses Through Downregulation of the Expression of Nitric Oxide Synthase 1 in Mice
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概要
- 論文の詳細を見る
Unsei-in inhibits substance P (SP)-induced scratching of mice after repeated administration. The involvement of cutaneous nitric oxide (NO) in the SP-induced scratching led us to investigate the effects of Unsei-in on the cutaneous NO system in mice. Seven-day oral administration of Unsei-in (300, but not 100, mg/kg daily) significantly inhibited scratching and the increase of cutaneous NO after intradermal SP injection. The NO synthase 1 (NOS1) inhibitor 7-nitroindazole (1 nmol/site) decreased SP-induced scratching and NO production. Repeated administration of Unsei-in (300 mg/kg) reduced the cutaneous NOS1 level. The results suggest that the inhibition of cutaneous NOS1 expression and NO production participates in the antipruritic action of Unsei-in.
- 社団法人 日本薬理学会の論文
- 2004-02-01
著者
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ANDOH Tsugunobu
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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NOJIMA Hiroshi
Department of Pharmacology, School of Pharmaceutical Sciences, Ohu University
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KURAISHI Yasushi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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Nagai Hiroichi
富山医科薬科大学和漢薬研究所
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Andoh Tsugunobu
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Kuraishi Yasushi
Department Of Applied Pharmacology Graduate School Of Medical And Pharmaceutical Science University
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Kuraishi Yasushi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Nojima H
Department Of Pharmacology School Of Pharmaceutical Sciences Ohu University
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AL-AKEEL Ali
Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences Toyama Medical and Pharmaceut
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TSUJII Kenichiro
Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences Toyama Medical and Pharmaceut
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Nagai Hiroichi
岐阜薬科大学 薬理
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Nojima Hiroshi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Al-akeel Ali
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Nemoto Hideo
Laboratory Of Medical Chemistry Graduate School Of Medicine And Pharmaceutical Sciences University O
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Andoh Tsugunobu
Department Of Applied Pharmacology Faculty Of Pharmaceu Tical Sciences
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Nagai Hiroichi
Department Of Pharmacology School Of Pharmaceutical Sciences Ohu University
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Nojima Hiroshi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Ohu University
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Tsujii Kenichiro
Department Of Applied Pharmacology Graduate School Of Medical And Pharmaceutical Science University
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Nojima H
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Kuraishi Yasushi
Department Of Applied Pharmacology Faculty Of Pharmaceu Tical Sciences
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Kuraishi Yasushi
Department Of Applide Biochemistry Research Institute For Wakan-yaku Toyama Toyama Medical And Pharm
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Nojima Hiroshi
Laboratory Of Medical Chemistry Graduate School Of Medicine And Pharmaceutical Sciences University O
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Nemoto Hideo
Laboratory Of Medical Chemistry Graduate School Of Medicine And Pharmaceutical Sciences University O
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Andoh Tsugunobu
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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