Endothelium-Dependent Potentiation of Prostaglandin F_<2α>Induced Contractions by (±)-[6]-Gingerol Is Inhibited by Cyclooxygenase- but Not Lipoxygenase-Inhibitors in Mouse Mesenteric Veins
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概要
- 論文の詳細を見る
The mechanism of potentiation of prostaglandin (PG) F_<2α>-induced contraction of mouse mesenteric veins by (±)-[6]-gingerol was investigated in vitro. (±)-[6]-Gingerol (0.3 mM) potentiated the maximal contraction response elicited by PGF_<2α> (0.28 mM) in the presence of intact vascular endothelium, but not in its absence (de-endothelialized preparations). The potentiating effect was completely inhibited by cyclooxygenase inhibitors (0.2 mM aspirin and 0.2 mM indomethacin) and partly by calcium antagonists (2 μM verapamil, 8 nM nitrendipine and 1 μM ryanodine), but not inhibited by nordihydroguaiaretic acid (NDGA), a lipoxygenase inhibitor and ONO-3708,a thromboxane (TX) A_2 antagonist. The potentiation by (±)-[6]-gingerol is also observed in mesenteric veins of streptozotocin-diabetic mice where the enhancement of PGF_<2α>-induced contraction is caused mainly by activation of lipoxygenase. The potentiaion of PGF_<2α>-induced contraction by (±)-[6]-gingerol may be caused by a cyclooxygenase-dependent release of vasoconstrictors, other than PGF_<2α> and TXA_2,or by inhibiting vasorelaxants released from endothelial cells of mouse mesenteric veins.
- 公益社団法人日本薬学会の論文
- 1998-08-15
著者
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NOJIMA Hiroshi
Department of Pharmacology, School of Pharmaceutical Sciences, Ohu University
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木村 郁子
富山医科薬科大学
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KIMURA Ikuko
Department of Chemical Pharmacology Faculty of Pharmaceutical Sciences, Toyama medical and Pharmaceu
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Nojima Hiroshi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Pancho Leonora
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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HATA Yukiko
Department of Legal Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University
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Kimura Ikuko
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmace
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Hata Yukiko
Department Of Legal Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical University
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Hata Y
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Kimura Ikuko
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Hata Yukiko
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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