Inhibitory Effects of Methanol Extracts of Herbal Medicines on Substance P-Induced Itch-Scratch Response
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概要
- 論文の詳細を見る
In a search for new anti-pruritic drugs we screened methanol extracts of 33 harbal medicines which have been used for cutaneous diseases for their antipruritic activity using substance P(SP) as a pruritogen in mice. When administered perorally 30 min before SP injection, methanol extracts of 6 of these herbal medicines, the root of Scrophularia ningpoensis HEMSL, the root of Patrinia villosa (THUNB.) JUSS, the fruit of Forsythia suspenna VAHL, the rhizome of Cimicifuga dahurica (TURCZ.) MAXIM., the aerial part of Schizonepeta tenuifolia BRIQ. and the fruit of Cnidium monnieri (L.) CUSS, inhibited SP-induced itch-scratch response at a dose of 200 mg/kg without affecting locomotor activity. Dose dependence of these 6 extracts (50-500mg/kg) was investigated and all of them inhibited SP-induced itch-scratch response, with extracts from Scrophularia ningpoensis, Schizonepeta tenuifolia and Cnidium monnieri showing particularly significant inhibition. The results suggest that these 6 methanol extracts have inhibitory activity against SP-induced itching.
- 公益社団法人日本薬学会の論文
- 2000-05-01
著者
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KURAISHI Yasushi
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, Univers
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Kuraishi Yasushi
富山医科薬科大学和漢薬研究所
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KOMATSU Katsuko
Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical
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TOHDA Chihiro
Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical
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Komatsu Katsuko
Research Center For Ethnomedicines Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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Kuraishi Yasushi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Tohda Chihiro
Research Center For Ethnomedicines Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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KAKIHARA Yumiko
Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceu
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Kakihara Yumiko
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Tohda Chihiro
Research Center For Ethnomedicine Institute Of Natural Medicine Toyama Medical And Pharmaceutical Un
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Kuraishi Yasushi
Department Of Applied Pharmacology Faculty Of Pharmaceu Tical Sciences
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Kuraishi Yasushi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Kuraishi Yasushi
Department Of Applide Biochemistry Research Institute For Wakan-yaku Toyama Toyama Medical And Pharm
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