Trigonelline-Induced Neurite Outgrowth in Human Neuroblastoma SK-N-SH Cells
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概要
- 論文の詳細を見る
Extension of dendrites and axons in neurons may compensate and rescue damaged neuronal networks in the dementia brain. Our aim is to isolate and identify constituents of coffee beans exhibiting neurite outgrowth activity. Among the extracts of raw and roasted coffee beans, a methanol fraction of the ethanol extract (1 μg/ml) of raw beans increased significantly the percentage of cells with neurites in human neuroblastoma SK-N-SH cells. Among subfractions of this methanol fraction was a basic fraction (5 μg/ml) wich exhibited significant neurite outgrowth activity. Finally, trigonelline in the basic fraction was identified to be active as far neurite extension was concerned. Treatment with trigonelline (30 μM) increased the percentage of cells with neurites at 3 and 6 d after treatment. In addition, the number of neurites reacting positively to phosphorylated neurofilament-H was increased by treatment with 30 μM trigonelline for 6d, suggesting enhancement of axonal extension. These results show that trigonelline promotes functional neurite outgrowth.
- 公益社団法人日本薬学会の論文
- 1999-07-15
著者
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花岡 美代次
金沢大学薬学部
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KOMATSU Katsuko
Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical
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Nakamura N
Faculty Of Pharmaceutical Sciences Doshisha Women's College Of Liberal Arts
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TOHDA Chihiro
Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical
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Hattori M
Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical University
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Hattori Masao
Department Of Metabolic Engineering Institute Of Natural Medicine Toyama Medical And Pharmaceutical
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NAKAMURA Norio
Department of Metabolic Engineering, Institute of Natural Medicine, Toyama Medical and Pharmaceutica
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Nakamura N
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Komatsu Katsuko
富山大学和漢医薬学総合研究所
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Komatsu Katsuko
Division Of Pharmacognosy Department Of Medicinal Resources Institute Of Natural Medicine Toyama Med
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Komatsu Katsuko
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Komatsu Katsuko
Research Center For Ethnomedicines Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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Komatsu K
Institute Of Natural Medicine University Of Toyama
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Hattori Masao
Department Of Cell-resources Engineering Research Institute For Wakan-yaku (traditional Sino-japanes
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Komatsu Katsuko
Division Of Pharmacognosy Department Of Medicinal Resources Istitute Of Natural Medicine University
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Tohda C
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Tohda Chihiro
富山大学和漢医薬学総合研究所 民族薬物研究センター 薬効解析部
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Tohda Chihiro
Division Of Biofunctional Evaluation Research Center For Ethnomedicine University Of Toyama
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Tohda Chihiro
Research Center For Ethnomedicine Institute Of Natural Medicine Toyama Medical And Pharmaceutical Un
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Nakamura Norio
Department Of Biology Yokohama City University
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Nakamura Norio
Department Of Anatomy Gunma University School Of Medicine
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