Two New Triterpenes from the Rhizome of Dryopteris crassirhizoma, and Inhibitory Activities of Its Constituents on Human Immunodeficiency Virus-1 Protease

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概要

• 論文の詳細を見る

• Two new hopane type triterpenes, named dryopteric acids A (1) and B (2), were isolated from the Rhizome of Dryopteris crassirhizoma (Aspiadaceae) together with sixteen known compounds (3-18). Of isolated compounds, ursolic acid (15), and dryopteric acid A (1) and B (2) showed potent inhibitory activities against HIV-1 protease with IC_<50> values of 8.9-44.5μM. In addition, acetylated compounds 1 and 2 appreciably increased inhibitory activities with their IC_<50> values of 1.7 and 10.8μM, respectively.

• 社団法人日本薬学会の論文
• 2008-05-01

著者

• NAKAMURA Norio

  富山医科薬科大学和漢薬研究所

• Nakamura N

  Institute Of Natural Medicine University Of Toyama

• 花岡 美代次

  金沢大学薬学部

• Nakamura Norio

  Institute Of Natural Medicine University Of Toyama

• HATTORI Masao

  Institute of Natural Medicine, University of Toyama

• Nakamura N

  Faculty Of Pharmaceutical Sciences Doshisha Women's College Of Liberal Arts

• Hattori Masao

  Institute Of Natural Medicine University Of Toyama

• Hattori Masao

  Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu

• Hattori M

  Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical University

• LEE Ji

  College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University

• MIYASHIRO Hirotsugu

  Institute of Natural Medicine, University of Toyama

• Nakamura N

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Hattori M

  Institute Of Natural Medicine University Of Toyama

• Hattori Masao

  Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences

• Hattori Masao

  Metabolic Engineering Institute Of Natural Medicine University Of Toyama

• Lee Ji

  College Of Pharmacy And Research Institute Of Pharmaceutical Sciences Seoul National University:inst

• Miyashiro H

  Institute Of Natural Medicine University Of Toyama

• Nakamura Norio

  Institute Of Natural Medicine Toyama And Pharmaceutical University

• Nakamura Norio

  Institute Of Natural Medicine

• 花岡 美代次

  Institute Of Natural Medicine University Of Toyama

• LEE Ji

  College of Arts and Science, University of Pennsylvania

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