Three New Lignans, Longipedunins A-C, from Kadsura longipedunculata and Their Inhibitory Activity against HIV-1 Protease

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概要

• 論文の詳細を見る

• Three new lignans, longipedunins A (1), B (2) and C (3), together with three known compounds, benzoyl-binankadsurin A (4), acetyl-binankadsurin A (5) and schisanlactone A (6), were isolated from Kadsura longipedunculata. Their structures and stereochemistry were determined by spectral and single-crystal X-ray analyses. Compounds 1 and 6 showed appreciable inhibitory activity against HIV-1 protease with IC_<50> values of 50 and 20μM, respectively.

• 社団法人日本薬学会の論文
• 2006-01-01

著者

• NAKAMURA Norio

  富山医科薬科大学和漢薬研究所

• Nakamura N

  Institute Of Natural Medicine University Of Toyama

• MA Chao-Mei

  Institute of Natural Medicine, University of Toyama

• Nakamura N

  Faculty Of Pharmaceutical Sciences Doshisha Women's College Of Liberal Arts

• Ma Chao-mei

  富山大学和漢医薬学総合研究所

• Hattori M

  Inst. Of Natural Medicine Univ. Of Toyama

• Hattori Masao

  Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu

• Hattori M

  Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical University

• Hattori Masao

  Department Of Metabolic Engineering Institute Of Natural Medicine Toyama Medical And Pharmaceutical

• NAKAMURA Norio

  Department of Metabolic Engineering, Institute of Natural Medicine, Toyama Medical and Pharmaceutica

• SUN Quan-Zhong

  Department of Pharmacognosy, School of Pharmacy, Fudan University

• CHEN Dao-Feng

  Department of Pharmacognosy, School of Pharmacy, Fudan University

• DING Pei-Lan

  Department of Pharmacognosy, School of Pharmacy, Fudan University

• MA Chao-Mei

  Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University

• KAKUDA Hiroko

  Laboratory of Chemistry, Toyama Medical and Pharmaceutical University

• Sun Quan-zhong

  Department Of Pharmacognosy School Of Pharmacy Fudan University

• Ding Pei-lan

  Department Of Pharmacognosy School Of Pharmacy Fudan University

• Chen Dao-feng

  Department Of Pharmacognosy School Of Pharmacy Fudan University

• Kakuda Hiroko

  Laboratory Of Chemistry Toyama Medical And Pharmaceutical University

• Kakuda Hiroko

  Department Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Nakamura N

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Hattori M

  Institute Of Natural Medicine University Of Toyama

• Hattori Masao

  Department Of Cell-resources Engineering Research Institute For Wakan-yaku (traditional Sino-japanes

• Hattori Masao

  Metabolic Engineering Institute Of Natural Medicine University Of Toyama

• Nakamura Norio

  Department Of Biology Yokohama City University

• Nakamura Norio

  Department Of Anatomy Gunma University School Of Medicine

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