Quantitative determination of maleic and succinic acid derivatives in the mycelium of Antrodia cinnamomea
スポンサーリンク
概要
- 論文の詳細を見る
樟芝菌糸体中の新規マレイン酸及び琥珀酸誘導体(antrodin A-E)の定量分析法を確立する目的で,高速液体クロマトグラフィー(HPLC)による分析条件を検討した。Antrodin A-Eは,移動相:1%AcOH/H_2O-CH_3CN (0 min, 60: 40; 40min, 30:70);流速:1.0ml/min;測定波長:235nm;カラム温度:室温の条件下,ODSカラムを用い定量を行った。この方法による日内と日間の相対的な標準偏差は4.6%及び4.1%(n=5)であり,0.1 (or 0.2)μgから1.2μgまでの濃度範囲で良好な直線性が得られた。Antrodin A-Eの回収率はそれぞれ,99.8, 102.9, 101.0, 100.5及び99.9%であった。本測定法は迅速且つ正確であり,樟芝菌糸体中の新規マレイン酸及び琥珀酸誘導体の定量に適していると考えられる。
- 2006-02-20
著者
-
服部 征雄
富山大学和漢医薬学総合研究所
-
NAKAMURA Norio
富山医科薬科大学和漢薬研究所
-
Zuo Feng
Institute Of Natural Medicine University Of Toyama
-
Nakamura Norio
Institute Of Natural Medicine University Of Toyama
-
HAN Hao-Feng
Institute of Natural Medicine, University of Toyama
-
HIRAKAWA Akiko
Institute of Natural Medicine, University of Toyama
-
Han Hao-feng
Metabolic Engineering Institute Of Natural Medicine University Of Toyama
-
Han Hao-feng
Institute Of Natural Medicine University Of Toyama
-
Hirakawa Akiko
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
-
Hirakawa Akiko
Institute Of Natural Medicine University Of Toyama
-
Hattori M
Inst. Of Natural Medicine Univ. Of Toyama
-
Hattori M
Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical University
-
Hattori Masao
Department Of Metabolic Engineering Institute Of Natural Medicine Toyama Medical And Pharmaceutical
-
服部 征雄
富山大学・和漢医薬学総合研究所薬物代謝工学
-
Zuo Feng
Institute Of Chinese Materia Medica China Academy Of Traditional Chinese Medicine
-
Hattori M
Institute Of Natural Medicine University Of Toyama
-
Nakamura N
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
-
Hattori Masao
Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences
-
Nakamura Norio
Institute Of Natural Medicine Toyama And Pharmaceutical University
-
Nakamura Norio
Institute Of Natural Medicine Facully Of Pharmaceutical Sciences And Pharmaceutical University
-
Nakamura Norio
Institute Of Natural Medicine
関連論文
- Effects of Tokishakuyakusan on the ovary in hypophysectomized rats
- Effects of Tokishakuyakusan on hypothalamic pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP type I receptor (PAC_1) expression in hypophysectomized and ovariectomized rats
- Simultaneous determination of ten bioactive constituents in Eucommia ulmoides leaves and Tochu tea products by high-performance liquid chromatography-diode array detector-mass spectrometry (HPLC-DAD-MS)
- Characterization of anti-herpes simplex virus type 1 activity of an alkaloid FK 3000 from Stephania cepharantha
- Human intestinal Bacteroides spp. RHEIN-I and RHEIN-II capable of transforming rhein to rheinanthrone, induce rhein-dependent diarrhea in rats
- P-2 丹参由来 Sodium tanshinone IIA sulfonate は Angiotensin II 誘導による培養心筋細胞肥大を軽減する
- L-097(30) 丹参製剤の適正使用のためのナレッジマネージメント : EBM の実践をめざして
- C-5 心疾患治療薬としての丹参の有効性と薬物間相互作用発現の可能性 : 心臓由来培養細胞ならびにヒト肝 CYP 代謝での検討
- 乳酸菌による植物リグナンの代謝
- Metabolism and pharmacokinetics in rats of ganoderiol F, a highly cytotoxic and antitumor triterpene from Ganoderma lucidum
- Pharmacokinetic study of benzoylmesaconine in rats using an enzyme immunoassay system
- Protective Effects of a Neutral Polysaccharide Isolated from the Mycelium of Antrodia cinnamomea on Propionibacterium acnes and Lipopolysaccharide Induced Hepatic Injury in Mice
- Quantitative Determination of Bitter Principles in Specimens of Ganoderma lucidum Using High-Performance Liquid Chromatography and Its Application to the Evaluation of Ganoderma Products
- Metabolism and Pharmacokinetics of Swertiamarin in Rats (The 24th Annual Meeting of Medical and Pharmaceutical Society for WAKAN-YAKU)
- 薬物代謝工学分野(資源開発部門,各部門・附属センターの活動と業績)
- Endothelium-dependent vasodilator effect of tannin extract from Cinnamonomi Cortex on isolated rat aorta
- Two New Triterpenes from the Rhizome of Dryopteris crassirhizoma, and Inhibitory Activities of Its Constituents on Human Immunodeficiency Virus-1 Protease
- Enantioselective Dehydroxylation of Enterodiol and Enterolactone Precursors by Human Intestinal Bacteria(Pharmacognosy)
- Developing of anti-HIV agents from natural resources(Chemical & Pharmacological study)
- A New Enzyme Immunoassay for Aconitine and Its Application to Quantitative Determination of Aconitine Levels in Plasma(Pharmacognosy)
- Sesquiterpenes and Alkaloids from Lindera chunii and Their Inhibitory Activities against HIV-1 Integrase
- Flavanone and Flavonol Glycosides from the Leaves of Thevetia peruviana and Their HIV-1 Reverse Transcriptase and HIV-1 Integrase Inhibitory Activities
- Inhibition of Cytopathic Effect of Human Immunodeficiency Virus Type-1 by Various Phorbol Derivatives
- The Heterocyclic Ring Fission and Dehydroxylation of Catechins and Related Compounds by Eubacterium sp.Strain SDG-2, a Human Intestinal Bacterium
- Triterpenes from the Spores of Ganoderma lucidum and Their Cytotoxicity against Meth-A and LLC Tumor Cells
- Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Ribonuclease H Activites by Constituents of Juglans mandshurica
- Metabolic activation of lignans to estrogenic and antiestrogenic substances by human intestinal bacteria
- Screening of medicinal plant extracts for estrogenic activity in combination with a glycosidase treatment
- Development of an enzyme immunoassay system for mesaconitine and its application to the disposition study on mesaconitine
- Enzyme immunoassay for the quantitative determination of ganoderic acid A from Ganoderma lucidum
- Biotransformation of C-Glucosylisoflavone Puerarin to Estrogenic (3S)-Equol in Co-culture of Two Human Intestinal Bacteria(Pharmacognosy)
- Estrogenic Effects of a Kampo Formula, Tokishakuyakman, in Parous Ovariectomized Rats(Pharmacology)
- New Lanostane Triterpene Lactones from the Vietnamese Mushroom Ganoderma colossum (FR.) C. F. BAKER
- Enantioselective Oxidation of Enterodiol to Enterolactone by Human Intestinal Bacteria(Pharmacognosy)
- Estrogenic and Anti-estrogenic Activities of Cassia tora Phenolic Constituents
- Anti-estrogenic Activity of Mansorins and Mansonones from the Heartwood of Mansonia gagei DRUMM.
- Isolation and Characterization of a Human Intestinal Bacterium, Eubacterium sp. ARC-2, Capable of Demethylating Arctigenin, in the Essential Metabolic Process to Enterolactone(Pharmacology)
- Protective effects of an acidic polysaccharide isolated from fruiting bodies of Ganoderma lucidum against murine hepatic injury induced by Propionibacterium acnes and lipopolysaccharide
- Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase
- In vivo antitumor effects of bitter principles from the antlered form of fruiting bodies of Ganoderma lucidum
- Three New Lignans, Longipedunins A-C, from Kadsura longipedunculata and Their Inhibitory Activity against HIV-1 Protease
- Antiviral Activity of the Marine Alga Symphyocladia latiuscula against Herpes Simplex Virus (HSV-1) in Vitro and Its Therapeutic Efficacy against HSV-1 Infection in Mice(Pharmacognosy)
- Two Proteins, Mn^, and Low Molecular Cofactor Are Required for C-Glucosyl-Cleavage of Mangiferin(Biochemistry)
- Isolation of a Human Intestinal Bacterium That Transforms Mangiferin to Norathyriol and Inducibility of the Enzyme That Cleaves a C-Glucosyl Bond(Pharmacognosy)
- Constituents of the seeds of Glycyrrhiza uralensis
- Chemical and Biological Evaluation of Germinated and Mature Antler-shaped Fruiting Bodies of Ganoderma lucidum
- Metabolism and Disposition of Antrodin C in Rats : Extreme Hepatic Transformation and Biliary Excretion(The 24th Annual Meeting of Medical and Pharmaceutical Society for WAKAN-YAKU)
- 薬物代謝工学分野(資源開発部門,各部門・附属センターの活動と業績)
- Novel pharmacological potential of Rhei Rhizoma against peroxynitrite-induced oxidative renal injury
- Effects of Japanese Black Tea on Atherosclerotic Disorders
- The Role of Total Ginseng Saponin and Its Components in Antiperoxidation in Vitro
- Effects on the Proliferation of Smooth Muscle Cells of Oriental Medical Prescriptions Used for the Treatment of Arteriosclerosis
- New Paeonilactone-A Adducts Formed by Anaerobic Incubation of Paeoniflorin with Lactobacillus brevis in the Presence of Arylthiols
- Anticonvulsant Activity of Paeonimetabolin-I Adducts Obtained by Incubation of Paeoniflorin and Thiol Compounds with Lactobacillus brevis
- Potent Anticonvulsant Paeonimetabolin-I Derivatives Obtained by Incubation of Paeoniflorin and Thiol Compounds with Lactobacillus brevis
- Quantitative determination of maleic and succinic acid derivatives in the mycelium of Antrodia cinnamomea
- Determination of novel nitrogen-containing metabolites after oral administration of swertiamarin to rats
- Quantification of ergosterol and ergosterol peroxide in several medicinal fungi by high performance liquid chromatography monitored with a diode array detection-atmospheric pressure chemical ionization-ion trap mass spectrometer
- P-48 卵巣摘出ラットを用いた当帰芍薬散と17β-エストラジオールの作用差に関する研究(女性医学・肝,一般演題ポスター,第24回和漢医薬学会大会 和漢薬の複雑さ-経験知と科学知-)
- 複合薬物代謝研究の夜明け(学会賞受賞講演,第24回和漢医薬学会大会 和漢薬の複雑さ-経験知と科学知-)
- 和漢薬研究所の過去、現在、そして将来
- 研究所年報 巻頭の言葉
- Conversion of aconitine lipoaconitine by human intestinal bacteria and their antinociceptive effects in mice
- Four Mono-tetrahydrofuran Ring Acetogenins, Montanacins B-E, from Annona montana
- 12-O-Acetylphorbol-13-decanoate Potently Inhibits Cytopathic Effects of Human Immunodeficiency Virus Type 1 (HIV-1), without Activation of Protein Kinase C
- Transformation of Arctiin to Estrogenic and Antiestrogenic Substances by Human Intestinal Bacteria
- Anti-herpes simplex virus activities of traditional Chinese medicines, used in Yunnan and Tibetan provinces of China
- Apocynins A-D : New Phenylpropanoid-substituted Flavan-3-ols Isolated from Leaves of Apocynum venetum (Luobuma-Ye)
- Protective effect of Sanguisorbae Radix against peroxynitrite-mediated renal injury
- Tinospora tuberculata Suppresses Nitric Oxide Synthesis in Mouse Macrophages
- Transformation of Ergosterol Peroxide to Cytotoxic Substances by Rat Intestinal Bacteria(Biopharmacy)
- Pharmacokinetic Study on the Multi-constituents of Huangqin-Tang Decoction in Rats
- Metabolism of Constituents in Huangqin-Tang, a Prescription in Traditional Chinese Medicine, by Human Intestinal Flora
- Determination of 14 Chemical Constituents in the Traditional Chinese Medicinal Preparation Huangqin-Tang by High Performance Liquid Chromatography
- Three New Triterpene Saponins from the Seeds of Aesculus chinensis
- Amino acids and phosphates stimulate hatching of Ochlerotatus koreicoides (Diptera : Culicidae) eggs
- Anti-complement Activity of Constituents from the Stem-Bark of Juglans mandshurica
- New Triterpene Aldehydes, Lucialdehydes A-C, from Ganoderma lucidum and Their Cytotoxicity against Murine and Human Tumor Cells
- Biotransformation of a C-Glycosylflavone, Abrusin 2"-O-β-D-Apioside, by Human Intestinal Bacteria
- Cytotoxic Alkaloids and a Flavan from the Bulbs of Crinum asiaticum var.japonicum
- Kaempferol Acetylrhamnosides from the Rhizome of Dryopteris crassirhizoma and Their Inhibitory Effects on Three Different Activities of Human Immunodeficiency Virus-1 Reverse Transcriptase
- Triterpenes and Lignans from Artemisia caruifolia and Their Cytotoxic Effects on Meth-A and LLC Tumor Cell Lines
- Inhibitory effect of Tibetan medicinal plants on viral polymerases
- Protective Effect of Salvia miltiorrhiza on Angiotensin II-Induced Hypertrophic Responses in Neonatal Rat Cardiac Cells
- Trigonelline-Induced Neurite Outgrowth in Human Neuroblastoma SK-N-SH Cells
- Inhibitory Effects of Triterpene-Azidothymidine Conjugates on Proliferation of Human Immunodeficiency Virus Type 1 and Its Protease
- Biotransformation of Phorbol by Human Intestinal Bacteria
- Estrogenic and Antiestrogenic Activities of the Roots of Moghania philippinensis and Their Constituents (Pharmacognosy)
- Human Intestinal Bacteria Capable of Transforming Secoisolariciresinol Diglucoside to Mammalian Lignans, Enterodiol and Enterolactone
- Inhibitory Effects on HIV-1 Protease of Tri-p-coumaroylspermidine from Artemisia caruifolia and Related Amides
- Absolute Configuration of Cipadesin and Febrifugin from the Seeds of Cipadessa baccifera
- Chemical Modification of Oleanene Type Triterpenes and Their Inhibitory Activity against HIV-1 Protease Dimerization
- Four New Saponins from the Root Bark of Aralia elata
- Inhibitory activities of Thai medicinal plants against herpes simplex type 1, poliovirus type 1, and measles virus
- 偶然からモノを見つけだす能力を生かす : 腸内細菌による和漢薬の代謝研究を振り返って
- Constituents of the seeds of Glycyrrhiza uralensis
- Chemical and Biological Evaluation of Germinated and Mature Antler-shaped Fruiting Bodies of Ganoderma lucidum
- Disposition of Paeoniflorin and Paeonimetabolin I in Rats after Oral Administration of Toki-Shakuyaku-San (TS) and Shakuyaku-Kanzo-To (SK)
- Absolute Configuration of Cipadesin and Febrifugin from the Seeds of Cipadessa baccifera(Natural Medicine Note)
- Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons