Effects of Tokishakuyakusan on the ovary in hypophysectomized rats
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概要
- 論文の詳細を見る
当帰芍薬散は古来より婦人科領域で使われている代表的漢方方剤の1つである。また下垂体摘出ラット卵巣では卵胞の発育遅延、骨密度の低下を引き起こすことが知られている。そこで我々は,ラットの下垂体摘出後,当帰芍薬散の経口投与を1週間行い,投与後の卵巣を解析した。下垂体摘出による卵巣重量低下を当帰芍薬散は回復させなかったが,子宮重量低下に対する回復はみられた。また,下垂体摘出により卵巣内StAR蛋白質のmRNA発現量は減少したが,当帰芍薬散を投与することにより発現量の回復がみられた。下垂体アデニル酸シクラーゼ活性化ポリペプチド受容体(PAC_1),プロゲステロン受容体(PR)のmRNA発現量は下垂体摘出により上昇したが,当帰芍薬散はこれを抑制した。しかし,エストロゲン受容体α(ERα)のmRNA発現量の変化は見られなかった。さらに組織学的観察より,当帰芍薬散は卵胞発達を促進する傾向が見られた。また,当帰芍薬散は骨代謝のマーカーである尿中DPDレベルの上昇を抑制した。以上の結果から,当帰芍薬散は卵巣における卵胞の発達を促進し,下垂体ホルモン由来の骨代謝を抑制することが示唆された。
- 2007-02-28
著者
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CHUNG Mi
Division of Metabolic Engineering, Institute of Natural Medicine, University of Toyama
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TOHDA Michihisa
Division of Medical Pharmacology, Institute of Natural Medicine, University of Toyama
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服部 征雄
富山大学和漢医薬学総合研究所
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Chung Mi
Division Of Metabolic Engineering Institute Of Natural Medicine University Of Toyama
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Hattori M
Inst. Of Natural Medicine Univ. Of Toyama
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Hattori M
Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical University
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Hattori Masao
Department Of Metabolic Engineering Institute Of Natural Medicine Toyama Medical And Pharmaceutical
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Tohda Michihisa
Division Of Medical Pharmacology Institute Of Natural Medicine University Of Toyama
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Hattori M
Institute Of Natural Medicine University Of Toyama
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Hattori Masao
Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences
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