Possible Involvement of Signal Transducers and Activators of Transcription 3 System on Depression in the Model Mice Brain
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概要
- 論文の詳細を見る
The aim of this study was to examine gene expression changes in the frontal cortex and hippocampus of animals with different susceptibility to stressful stimuli. Using a learned helplessness (LH) paradigm, mice received moderate current stimulation to induce different extents of LH behavior. Changes in mRNA expression were investigated by microarray and semiquantitative reverse transcription-polymerase chain reaction (RT-PCR). Comparisons of expression profiles between LH and control or non-learned helplessness (non-LH) animals revealed that the signal transducers and activators of transcription 3 (Stat3)-interacting protein (StIP1) gene is downregulated in LH animals and the suppressor of cytokine signaling 3 (Socs3) gene is up-regulated in non-LH animals. Since both StIP1 and Socs3 regulate the activity of Stat3 gene, these results suggest that Stat3 systems may be involved in the pathogenesis of depressive disorders.
- 日本薬学会の論文
著者
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TOHDA Michihisa
Division of Medical Pharmacology, Institute of Natural Medicine, University of Toyama
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Tohda Michihisa
和漢医薬学総合研究所 複合薬物薬理学分野
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Tohda Michihisa
富山医科薬科大学和漢薬研究所
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Tohda Michihisa
タイ
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Tohda Michihisa
和漢医薬学総合研究所 複合薬物薬理学
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MURAKAMI Yukihisa
Division of Medicinal Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical
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MATSUMOTO Kinzo
Division of Medicinal Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical
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Murakami Yukihisa
富山大学和漢医薬学総合研究所 複合薬物薬理学
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Mukarami Yukihisa
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Murakami Yukihisa
Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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Murakami Yukihisa
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines)
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Mingmalairak Salin
Division of Medicinal Pharmacology, Institute of Natural Medicine, University of Toyama
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Murakami Yuko
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Tohda Michihisa
Division Of Medical Pharmacology Institute Of Natural Medicine University Of Toyama
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Matsumoto Kinzo
Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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Murakami Y
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Murakami Y
Toho Univ. Chiba Jpn
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東田 道久
Division Of Medicinal Pharmacology Institute Of Natural Medicine University Of Toyama
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Murakami Yukihisa
Division of Medicinal Pharmacology, Institute of Natural Medicine, University of Toyama
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