Inhibitory Effect of Alkaloids Extracted from the Stem Bark of Hunteria zeylanica on 5-Lipoxygenase Activity in Vitro
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概要
- 論文の詳細を見る
The effects of alkaloid extract from the stem bark of Hunteria zeylanica GARD. (H. zeylanica) on the activities of cyclooxygenase and 5-lipoxygenase in A23187-stimulated rat mast cells were investigated. H. zeylanica alkaloid extract (0.3-300μg/ml) inhibited leukotriene C_4 (LTC_4) production by 5-lipoxygenase in a concentration-dependent manner and it blocked the production by 50% at 300 μg/ml. On the other hand, the extract had no effect on prostaglandin D_2 (PGD_2) production by cyclooxygenase. Neither (-)-eburnamine nor pleiomutinine, major constituents of H. zeylanica alkaloid extract, inhibited the production of PGD_2 and LTC_4 in the A23187-stimulated mast cells. The inhibition of arachidonic acid metabolism via 5-lipoxygenase pathway may be due to minute amounts of other components as stated in the Discussion.
- 社団法人日本薬学会の論文
- 1995-06-15
著者
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坂井 進一郎
千葉大院薬
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坂井 進一郎
Department of Medicinal Materials
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Tohda Michihisa
和漢医薬学総合研究所 複合薬物薬理学分野
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渡辺 裕司
International Research Center For Traditional Medicine Toyama Prefecture International Health Comple
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松本 欣三
Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines) Toyama Medical and
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渡辺 裕司
Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines) Toyama Medical and
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高山 廣光
Graduate School Of Pharmaceutical Sciences Chiba Univ.
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松本 欣三
富山大学和漢医薬学総合研究所複合薬物薬理学
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SUBHADHIRASAKUL Sanan
Department of Pharmaceutical Botany and Pharmacognosy, Faculty of Pharmaceutical Sciences, Prince of
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REANMONGKOL Wantana
Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and
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東田 道久
Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and
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高山 広光
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chiba University
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Matsumoto Kinzo
Division Of Pharmacology Research Institute For Wakan-yaku (oriental Medicines)
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佐々木 茂貴
Faculty Of Pharmaceutical Sciences Kyushu University
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Takayama Hiromitsu
Laboratory Of Molecular Structure And Biological Function Graduate School Of Pharmaceutical Sciences
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Reanmongkol Wantana
Division Of Pharmacology Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And P
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坂井 進一郎
Thailand And Department Of Pharmaceutical Chemistry Faculty Of Pharmaceutical Sciences Chiba Univers
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東田 道久
Division Of Medicinal Pharmacology Institute Of Natural Medicine University Of Toyama
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Subhadhirasakul Sanan
Department Of Pharmaceutical Botany And Pharmacognosy Faculty Of Pharmaceutical Sciences Prince Of S
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Subhadhirasakul Sanan
Department of Molecular Medicinal Sciences, Graduate School of Biomedical Sciences, Nagasaki University
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/ 東田
Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University
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渡辺 裕司
Division of Medicinal Pharmacology, Institute of Natural Medicine, University of Toyama
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