Effects of Mitragynine on cAMP Formation Mediated by δ-Opiate Receptors in NG108-15 Cells
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概要
- 論文の詳細を見る
Mitragynine, a major constituent of the young leaves of Mitragyna speciosa KORTH., has been reported to exert antinociceptive activity in mice. To determine the mechanism the influence of mitragynine on cAMP content was measured in NG108-15 cells which possess δ opioid receptors and α2B-adrenoceptors. Mitragynine inhibited the forskolin-stimulated cAMP content in a concentration dependent manner as well as morphine and noradrenaline. Mitragynine- and morphine-induced inhibition of cAMP content were blocked by naloxone. Although idazoxane inhibited noradrenaline-induced inhibition of the cAMP content, idazoxane had no effect on mitragynine-induced inhibition. These results suggest that mitragynine acts directly on opioid receptors, but not on α2-adrenoceptors, to show antinociceptive activity.
- 社団法人日本薬学会の論文
- 1997-04-15
著者
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TOHDA Michihisa
Division of Medical Pharmacology, Institute of Natural Medicine, University of Toyama
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Tohda Michihisa
和漢医薬学総合研究所 複合薬物薬理学分野
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MURAKAMI Yukihisa
Division of Medicinal Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical
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MATSUMOTO Kinzo
Division of Medicinal Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical
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渡辺 裕司
International Research Center For Traditional Medicine Toyama Prefecture International Health Comple
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Watanabe Hiroshi
Division of Infectious Diseases, Department of Infectious Medicine, Kurume University School of Medi
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高山 廣光
Graduate School Of Pharmaceutical Sciences Chiba Univ.
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Murakami Yukihisa
富山大学和漢医薬学総合研究所 複合薬物薬理学
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Mukarami Yukihisa
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Murakami Yukihisa
Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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Murakami Yukihisa
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines)
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Shirakawa Seiichiro
Faculty Of Pharmaceutical Sciences Chiba University
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THONGPRADITCHOTE Suchitra
Division of Pharmacology, Research Institute of Wakan-yaku (Oriental Medicines), Toyama Medical and
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SAKAI Shin-ichiro
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chiba University
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AIMI Norio
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chiba University
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TAKAYAMA Hiromitsu
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chiba University
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TONGROACH Pavich
Department of Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University
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Tohda Michihisa
Division Of Medical Pharmacology Institute Of Natural Medicine University Of Toyama
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Matsumoto Kinzo
Div. Of Medicinal Pharmacology Inst. Of Natural Medicine Univ. Of Toyama
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Matsumoto Kinzo
Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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Takayama Hiromitsu
Laboratory Of Molecular Structure And Biological Function Graduate School Of Pharmaceutical Sciences
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Matsumoto Kinzo
富山大学和漢医薬学総合研究所 複合薬物薬理学
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Watanabe Hiroshi
Division Of Cardiology Niigata University Graduate School Of Medical And Dental Science
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Murakami Y
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Aimi N
Graduate School Of Pharmaceutical Sciences Chiba University
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Thongpraditchote Suchitra
Division Of Pharmacology Research Institute Of Wakan-yaku (oriental Medicines) Toyama Medical And Ph
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Tongroach Pavich
Department Of Physiology Faculty Of Pharmaceutical Sciences Chulalongkorn University
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Watanabe Hiroshi
Division Of Cardiology Hemotology And Endocrinology Niigata University Graduate School Of Medical And Dental Science
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