Chotosan Enhances Macrophage Colony-Stimulating Factor mRNA Expression in the Ischemic Rat Brain and C6Bu-1 Glioma Cells(Biochemistry)

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概要

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• Macrophage colony stimulating factor (M-CSF) is a cytokine which has been recently reported to have a neuroprotective effect on ischemic rat brain. In this study, we investigated the effect of chotosan, an oriental medicine, which has been clinically demonstrated to be effective for the treatment of vascular dementia, on M-CSF gene expression in rats with permanent occlusion of bilateral common carotid arteries (P2VO) in vivo and in a C6Bu-1 glioma cell line in vitro. The expression level of M-CSF mRNA in the cerebral cortices of P2VO rats was significantly higher than that in the cerebral cortices of sham-operated animals. Repeated treatment of P2VO rats with chotosan (75mg/kg per day) for 4d after P2VO significantly increased the expression level of M-CSF mRNA in the cortex but it had no effect on the expression of β-actin, granulocyte colony stimulating factor (G-CSF), granulocyte/macrophage colony stimulating factor (GM-CSF) mRNAs. Moreover, the present in vitro studies revealed that chotosan treatment (10-100μg/ml) of C6Bu-1 glioma cells dose-dependently enhanced M-CSF mRNA expression without affecting the expression of G-CSF, GM-CSF, and inducible nitric oxide synthase mRNAs. The effect of chotosan was reversed by Ro 31-8220 (1μM), a selective protein kinase C (PKC) inhibitor, but not by H-89 (10μM), a selective protein kinase A (PKA) inhibitor. These findings suggest that the upregulatory effect of chotosan on M-CSF mRNA expression involves PKC and may play an important role in the antivascular dementia action of this formula.

• 社団法人日本薬学会の論文
• 2007-12-01

著者

• TOHDA Michihisa

  Division of Medical Pharmacology, Institute of Natural Medicine, University of Toyama

• 渡邉 裕司

  富山医科薬科大学和漢薬研究所生物試験部門

• Tohda Michihisa

  和漢医薬学総合研究所 複合薬物薬理学分野

• Tohda Michihisa

  富山医科薬科大学和漢薬研究所

• Tohda Michihisa

  タイ

• Tohda Michihisa

  和漢医薬学総合研究所 複合薬物薬理学

• MURAKAMI Yukihisa

  Division of Medicinal Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical

• MATSUMOTO Kinzo

  Division of Medicinal Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical

• 渡辺 裕司

  International Research Center For Traditional Medicine Toyama Prefecture International Health Comple

• Murakami Yukihisa

  富山大学和漢医薬学総合研究所 複合薬物薬理学

• Mukarami Yukihisa

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Murakami Yukihisa

  Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U

• Murakami Yukihisa

  Research Institute For Wakan-yaku (traditional Sino-japanese Medicines)

• SHIMADA Yutaka

  Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni

• GOTO Hirozo

  Department of Kampo Diagnostics, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Un

• 渡邉 浩司

  富山医科薬科大学和漢薬研究所生物試験部門

• Obi Ryosuke

  Department of Japanese Oriental Medicine, Toyama Medical and Pharmaceutical University

• Goto Hirozo

  Department Of Japanese Oriental Medicine Graduate School Of Medicine And Pharmaceutical Sciences Uni

• Shimada Y

  Tokyo Inst. Technol. Yokohama Jpn

• Murakami Yuko

  Department Of Bioactive Molecules National Institute Of Infectious Diseases

• Tohda Michihisa

  Division Of Medical Pharmacology Institute Of Natural Medicine University Of Toyama

• Tohda Michihisa

  Department Of Pharmacology Institute Of Natural Medicine (wakan-yaku) Toyama Medical And Pharmaceuti

• Matsumoto Kinzo

  Div. Of Medicinal Pharmacology Inst. Of Natural Medicine Univ. Of Toyama

• Matsumoto Kinzo

  Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U

• Shimada Yuji

  Microsystem Research Center Precision And Intelligence Laboratory Tokyo Institute Of Technology

• ZHAO Qi

  Division of Medicinal Pharmacology, Institute of Natural Medicine,University of Toyama

• OBI Nobuko

  Department of Japanese Oriental Medicine, Graduate School of Medicine and Pharmaceutical Sciences, U

• HORI Hitomi

  Division of Medicinal Pharmacology, Institute of Natural Medicine, University of Toyama

• OCHIAI Hiroshi

  Department of Human Science, Faculty of Medicine, University of Toyama

• Shimada Y

  Tohoku Univ. Sendai Jpn

• Matsumoto K

  Div. Of Medicinal Pharmacology Inst. Of Natural Medicine Univ. Of Toyama

• Zhao Qi

  Division Of Medicinal Pharmacology Institute Of Natural Medicine University Of Toyama

• Zhao Qi

  Division Of Pharmacology Institute Of Natural Medicine Toyama Medical & Pharmaceutical Universit

• Goto Hirozo

  Department Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama

• Watanabe H

  Health Science University Of Hokkaido

• 嶋田 豊

  富山医科薬科大学医学部和漢診療学

• Watanabe Hiroshi

  Radia Industry Co. Ltd

• Matsumoto Kinzo

  富山大学和漢医薬学総合研究所 複合薬物薬理学

• Murakami Y

  Department Of Bioactive Molecules National Institute Of Infectious Diseases

• Ochiai Hiroshi

  Department Of Human Science Faculty Of Medicine Toyama Medical And Pharmaceutical University.

• Obi Nobuko

  Department Of Japanese Oriental Medicine Graduate School Of Medicine And Pharmaceutical Sciences Uni

• Obi Ryosuke

  Division Of Medicinal Pharmacology Institute Of Natural Medicine University Of Toyama:department Of

• Obi Ryosuke

  Department Of Japanese Oriental Medicine Graduate School Of Medical And Pharmaceutical Sciences Univ

• Hori Hitomi

  Division Of Medicinal Pharmacology Institute Of Natural Medicine University Of Toyama

• Murakami Y

  Toho Univ. Chiba Jpn

• 渡邉 裕司

  富山医科薬科大学生物試験部門

• Tohda M

  Department Of Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universit

• 島田 洋蔵

  Dept. Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama

• Shimada Yutaka

  Department Of Anatomy And Cell Biology School Of Medicine Chiba Unversity

• Shimada Yutaka

  Department Of Japanese Oriental Medicine Faculty Of Medicine

• Shimada Yutaka

  21^<st> Century Coe Program Toyama Medical And Pharmaceutical University

• 東田 道久

  Division Of Medicinal Pharmacology Institute Of Natural Medicine University Of Toyama

• Ochiai Hiroshi

  Department Of Biochemistry And Biotechnology Faculty Of Agriculture And Life Science Hirosaki Univer

• Ochiai Hiroshi

  Department Of Human Science Faculty Of Medicine University Of Toyama:21st Century Coe Program Univer

• Watanabe Hiroshi

  Biotechnology Laboratory Japan Atomic Energy Research Institute

• Shimada Yutaka

  Department Of Anatomy And Cell Biology School Of Medicine Chiba University

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