Effects of Choto-san and Its Related Constituents on Endogenous Antioxidant Systems(Pharmacology)
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概要
- 論文の詳細を見る
We previously reported that Choto-san acts as an antioxidant and cytoprotective agents against H_2O_2-induced oxidative damage in NG108-15 cells, and the effect is due at least partly to the phenolic compounds. To further investigate the detail mechanisms of this cytoprotection effects of Choto-san and related compounds on enzyme activities of antioxidant systems were examined. Choto-san (5-100μg/ml) and Chotoko (5-100mg/ml) stimulated the activity of superoxide dismutase (SOD), catalase and glutathione peroxidase (GPX). These also increased the level of glutathione. Although Choto-san without Chotoko (w/o CKO) did not show the effects on SOD and catalase, GPX activity and glutathion content also, but weakly, stimulated by w/o CKO. The effects of phenolic compounds, epicatechin, caffeic acid and quercetin were also investigated. Epicatechin stimulated catalase, GPX and glutathion content, but not SOD. On the other hand, caffeic acid stimulated SOD activity but had no effects on others. Quercetin stimulated all, although intensities were different among. These results suggest that simultaneous induction of cellular antioxidant defense systems by Choto-sam and its related constituents may be an important mechanisms underlying the protective effects of Choto-san on ischemia-induced neuronal cells injury, and the characteristics of the stimulative effects of phenolic compounds were depend on enzymes.
- 2005-01-01
著者
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TOHDA Michihisa
Division of Medical Pharmacology, Institute of Natural Medicine, University of Toyama
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渡邉 裕司
富山医科薬科大学和漢薬研究所生物試験部門
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Tohda Michihisa
和漢医薬学総合研究所 複合薬物薬理学分野
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Tohda Michihisa
富山医科薬科大学和漢薬研究所
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Tohda Michihisa
タイ
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Tohda Michihisa
和漢医薬学総合研究所 複合薬物薬理学
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MURAKAMI Yukihisa
Division of Medicinal Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical
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MATSUMOTO Kinzo
Division of Medicinal Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical
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渡辺 裕司
International Research Center For Traditional Medicine Toyama Prefecture International Health Comple
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Watanabe Hiroshi
Division of Infectious Diseases, Department of Infectious Medicine, Kurume University School of Medi
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MAHAKUNAKORN Pramote
Division of Medicinal Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical
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Murakami Yukihisa
富山大学和漢医薬学総合研究所 複合薬物薬理学
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Mukarami Yukihisa
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Murakami Yukihisa
Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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Murakami Yukihisa
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines)
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渡邉 浩司
富山医科薬科大学和漢薬研究所生物試験部門
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Murakami Yuko
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Tohda Michihisa
Division Of Medical Pharmacology Institute Of Natural Medicine University Of Toyama
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Tohda Michihisa
Department Of Pharmacology Institute Of Natural Medicine (wakan-yaku) Toyama Medical And Pharmaceuti
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Matsumoto Kinzo
Div. Of Medicinal Pharmacology Inst. Of Natural Medicine Univ. Of Toyama
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Matsumoto Kinzo
Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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Matsumoto K
Div. Of Medicinal Pharmacology Inst. Of Natural Medicine Univ. Of Toyama
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Watanabe H
Health Science University Of Hokkaido
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Watanabe Hiroshi
Radia Industry Co. Ltd
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Mahakunakorn Pramote
Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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Matsumoto Kinzo
富山大学和漢医薬学総合研究所 複合薬物薬理学
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Watanabe Hiroshi
Division Of Cardiology Niigata University Graduate School Of Medical And Dental Science
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Murakami Y
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Murakami Y
Toho Univ. Chiba Jpn
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渡邉 裕司
富山医科薬科大学生物試験部門
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Tohda M
Department Of Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universit
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東田 道久
Division Of Medicinal Pharmacology Institute Of Natural Medicine University Of Toyama
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Watanabe Hiroshi
Biotechnology Laboratory Japan Atomic Energy Research Institute
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Watanabe Hiroshi
Division Of Cardiology Hemotology And Endocrinology Niigata University Graduate School Of Medical And Dental Science
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