Anti-hypertensive and anti-stroke effects of Chrysanthemum extracts in stroke-prone spontaneously hypertensive rats
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概要
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Chrysanthemum flower is a herb included in several Kampo formulae such as chotosan. In this study, we investigated the effects of Chrysanthemum flower produced in Hubei (K1) and Guangdong (K2) provinces in China on the blood pressure and expressions of genes encoding nitric oxide synthase (NOS) and muscarinic receptor subtypes in the brain, using stroke-prone spontaneously hypertensive rats (SHR-SP). Administration of test drugs [K1 and K2 extracts: 1-2g (dried herb weight)/kg/day, p.o.; nicardipine (NIC); 100mg/kg/day, p.o., once daily for 4 weeks] was started when the average blood pressures of the animals reached≥170mmHg. K1 and K2 (2g/kg/day), as well as NIC (100mg/kg/day), produced a significant decrease in the average blood pressure without affecting the heart rate during the 4-week period of drug administration; however, the blood pressures of the drug-treated groups returned to the vehicle-treated control level within a 2-week washout period. Stroke-associated symptoms and changes in gene expression of some hypertension-related biomarkers in the brain were assessed in SHR-SP after re-starting drug administration. K1 (1-2g/kg/day), K2 (1-2g/kg/day), and NIC (100mg/kg/day) significantly reduced the incidence of stroke-associated symptoms in SHR-SP. Moreover, the expression levels of genes encoding eNOS and nNOS, and M_3 and M_5 muscarinic receptors, but not those of genes encoding iNOS and M_2 and M_4 muscarinic receptors in the brain were significantly increased by K1 (1g/kg/day), K2 (2g/kg/day), and NIC (100mg/kg/day). These results suggest that Chrysanthemum K1 and K2 exhibit antihypertensive effects in a SHR-SP model and that the elevation of genes for NOS systems and M_3 and M_5 muscarinic receptors is relevant to the antihypertensive effects of this herb.
- 2008-11-29
著者
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MATSUMOTO Kinzo
Division of Medicinal Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical
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SAKAKIBARA Iwao
Tsumura and Co., Pharmacology Research Department, R&D Division
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ICHIKI Hiroyuki
Tsumura Central Research Laboratories, Tsumura and Co.
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Matsumoto Kinzo
Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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Matsumoto Kinzo
Division Of Medicinal Pharmacology Institute Of Natural Medicine University Of Toyama:21st Coe Progr
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ZHAO Qi
Division of Medicinal Pharmacology, Institute of Natural Medicine,University of Toyama
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OKADA Hideko
Tsumura & Co.
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Zhao Qi
Division Of Medicinal Pharmacology Institute Of Natural Medicine University Of Toyama
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Zhao Qi
Division Of Medicinal Pharmacology Institute Of Natural Medicine University Of Toyama:21st Coe Progr
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Okada Hideko
Tsumura & Co.
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Sakakibara Iwao
Tsumura & Co.
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Ichiki Hiroyuki
Tsumura & Co.
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