Protective effect of the hooks and stems of Uncaria sinensis against nitric oxide donor-induced neuronal death in cultured cerebellar granule cells
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概要
- 論文の詳細を見る
培養ラット小脳顆粒細胞を用いて,NO donor誘導神経細胞死に対する釣藤鈎エキスの保護作用を検討した。NO donorにはsodium nitroprusside(SNP) と 3-morpholinosydnonimine (SIN-1)を用い,細胞生存率の評価にはMTT法を用いた。釣藤鈎エキス(10,30,100μg/ml)は,SNP(30μM)6,12,24時間添加による神経細胞死を有意に抑制した。釣藤鈎エキス(10,30μg/ml)は,SIN-1(300μM)6,12,24時間添加による神経細胞死を有意に抑制した。釣藤鈎エキスのフェノール画分は,10,30μg/mlの濃度でSNP(30μM,24時間)添加による神経細胞死を有意に抑制し,同じく3,10μg/mlの濃度でSIN-1(300μM,24時間)添加による神経細胞死を有意に抑制した。釣藤鈎エキスのアルカロイド画分(30,100g/ml)は,SNP(30μM,24時間)およびSIN-1(300μM,24時間)添加による神経細胞死を有意に抑制した。以上より,釣藤鈎エキスはNO donorによって誘導される神経細胞死に対して保護作用を有し,その活性は釣藤鈎のフェノール画分およびアルカロイド画分にあることが示唆された。
- 和漢医薬学会の論文
- 2002-02-20
著者
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TERASAWA Katsutoshi
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni
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Terasawa Katsutoshi
群馬大学 医学部医学科統合和漢診療学講座
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SEKIYA Nobuyasu
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni
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SHIMADA Yutaka
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni
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Terasawa K
Dept. Of Japanese Oriental Medicine Graduate School Of Medicine Chiba University
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SAKAI Shinya
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni
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GOTO Hirozo
Department of Kampo Diagnostics, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Un
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Shimada Y
Dept. Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama
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SAKAKIBARA Iwao
Tsumura and Co., Pharmacology Research Department, R&D Division
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YOKOYAMA Koichi
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni
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Goto Hirozo
Toyama Medical and Pharmaceutical University
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MANTANI NAOKI
Department of Integrated Japanese Oriental Medicine, Faculty of Medicine
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Goto H
Department Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama
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Goto Hirozo
富山大学 大学院医学薬学研究部和漢診療学講座
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Goto Hirozo
Department Of Kampo Diagnostics Institute Of Natural Medicine University Of Toyama
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Shimada Y
Tokyo Inst. Technol. Yokohama Jpn
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Sakai Shinya
Department Of Japanese Oriental Medicine Faculty Of Medicine
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Sakai Shinya
Department Of Health Science Hokkaido University
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Mantani N
Department Of Integrated Japanese Oriental Medicine Faculty Of Medicine Gunma University
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Mantani Naoki
Departments Of Oriental Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical University
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Mantani Naoki
Department Of General Medicine Gunma University School Of Medicine
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Shimada Yuji
Microsystem Research Center Precision And Intelligence Laboratory Tokyo Institute Of Technology
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Shimada Y
Tohoku Univ. Sendai Jpn
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島田 洋蔵
産業技術総合研究所
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Goto Hirozo
Department Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama
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Sekiya Nobuyasu
Department Of Japanese Oriental Medicine Faculty Of Medicine
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嶋田 豊
富山医科薬科大学医学部和漢診療学
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Shibahara Naotoshi
Department Of Kampo Diagnostics Institute Of Natural Medicine University Of Toyama : 21st Century Co
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Sakakibara I
Pharmacognosy And Medicinal Resources Research Department Tsumura And Co.
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Sakakibara Iwao
Tsumura & Co. Ibaraki Jpn
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Sakakibara Iwao
Tsumura & Co.
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Yokoyama Koichi
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Goto Hirozo
Department Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama : 21st Century Coe
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Sekiya N
Department Of Japanese Oriental Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Unive
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島田 洋蔵
Dept. Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama
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Shimada Yutaka
Department Of Anatomy And Cell Biology School Of Medicine Chiba Unversity
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Terasawa Katsutoshi
Department Of Japanese Oriental Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Unive
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Shimada Yutaka
21^<st> Century Coe Program Toyama Medical And Pharmaceutical University
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Yokoyama Koichi
Department Of Japanese Oriental Medicine Faculty Of Medicine
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Shimada Nobuyasu
Department Of Japanese Oriental Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Unive
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Terasawa Katsutoshi
Department Of Japanese Oriental (kampo) Medicine Faculty Of Medicine Toyama Medical And Pharmaceutic
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Shimada Yutaka
Department Of Anatomy And Cell Biology School Of Medicine Chiba University
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Terasawa Katsutoshi
Department Of Integrated Japanese Oriental Medicine School Of Medicine Gunma University
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Yokoyama Koichi
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University
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YOKOYAMA Koichi
Depart-ment of Internal Medicne Yamagata Prefectural Central Hospital
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