Changes of peripheral lymphocyte population in patients with chronic hepatitis C treated with herbal medicine (Maoto) and IFN-β
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概要
- 論文の詳細を見る
我々は最近, 麻黄湯にはIFNβと併用療法時において免疫修飾作用があるのではないかと報告してきた。そこで今回我々は麻黄湯とIFNβ併用療法時における宿主の免疫反応とウイルス学的効果の関連性について検討する為に, フローサイトメトリー解析を用いて, 併用療法前後での末梢血リンパ球サブセットの変化について検討した。25名のC型慢性肝炎患者を対象として8週間の麻黄湯とIFNβの併用療法を行った。また麻黄湯はIFN投与中1日4回服用とした。ウイルス学的検討では, 6名が著効群(SR), 10名が一過性有効群(TR), 9名が無効群(NR)だった。CD16^+CD56^+陽性リンパ球数の比率は, 治療前と比較して, 4週後には3群ともその比率が低下したが, 4週から8週後では, SR群でTR群とNR群と比較して有意な上昇が認められた。またHLADR^+CD8^+リンパ球数の比率は治療前後においてSR群とTR群でNR群と比較して有意な上昇が認められた。我々の結果より, C型慢性肝炎に対する麻黄湯とIFNβ併用療法時において, CD16^+CD56^+, HLADR^+CD8^+リンパ球数の変化をモニタリングすることが有用である可能性が示唆された。
- 和漢医薬学会の論文
- 2005-06-20
著者
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貝沼 茂三郎
飯塚病院東洋医学センター漢方診療科
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KOGURE TOSHIAKI
Department of Integrated Japanese Oriental Medicine, School of Medicine, Gunma University
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Terasawa Katsutoshi
富山医科薬科大学和漢薬研究所
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SEKIYA Nobuyasu
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni
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MITSUMA Tadamichi
Department of Japanese Oriental Medicine, Iizuka Hospital
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SHIMADA Yutaka
Century COE Program, University of Toyama
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Terasawa Katsutoshi
Century COE Program, Toyama Medical and Pharmaceutical University
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Shimada Yutaka
富山大学 大学院医学薬学研究部和漢診療学講座
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Shimada Y
Department Of Japanese Oriental Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Unive
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SHIMADA Yutaka
Faculty of Medicine, Toyama Medical and Pharmaceutical University
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Sekiya Nobuyasu
Department Of Japanese Oriental Medicine Faculty Of Medicine
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Kogure Toshiaki
Department Of Integrated Japanese Oriental Medicine Faculty Of Medicine Gunma University School Of M
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Mitsuma Tadamichi
Department Of Japanese Oriental Medicine (kampo) Oriental Medical Center Iizuka Hospital
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Mitsuma Tadamichi
Department Of Japanese Oriental (kampo) Medicine Iizuka Hospital
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Shibahara Naotoshi
Department Of Kampo Diagnostics Institute Of Natural Medicine University Of Toyama : 21st Century Co
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Shimada Nobuyasu
Department Of Japanese Oriental Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Unive
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Terasawa Katsutoshi
21^<st> Century Coe Program Toyama Medical And Pharmaceutical University
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Shimada Yutaka
The 21st Century Coe Program Toyama Medical And Pharmaceutical University:department Of Japanese Ori
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Shimada Yutaka
富山医科薬科大学医学部和漢診療学教室
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Shimada Yutaka
Department Of Japanese Oriental Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Unive
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Shimada Yutaka
Department Of Anatomy And Cell Biology School Of Medicine Chiba University
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Terasawa Katsutoshi
21^ Century COE Program, Toyama Medical and Pharmaceutical University
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小暮 敏明
Department of Integrated Japanese Oriental Medicine, Faculty of Medicine, Gunma University School of Medicine
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