Potential in a Single Cancer Cell to Produce Heterogeneous Morphology, Radiosensitivity and Gene Expression
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概要
- 論文の詳細を見る
Morphologically heterogeneous colonies were formed from a cultured cell line (KYSE70) established from one human esophageal carcinoma tissue. Two subclones were separated from a single clone (clone 13) of KYSE70 cells. One subclone (clone 13-3G) formed mainly mounding colonies and the other (clone 13-6G) formed flat, diffusive colonies. X-irradiation stimulated the cells to dedifferentiate from the mounding state to the flat, diffusive state. Clone 13-6G cells were more radiosensitive than the other 3 cell lines. Clustering analysis for gene expression level by oligonucleotide microarray demonstrated that in the radiosensitive clone 13-6G cells, expression of genes involved in cell adhesion was upregulated, but genes involved in the response to DNA damage stimulus were downregulated. The data demonstrated that a single cancer cell had the potential to produce progeny heterogeneous in terms of morphology, radiation sensitivity and gene expression, and irradiation enhanced the dedifferentiation of cancer cells.
- 日本放射線影響学会の論文
- 2005-03-25
著者
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Imai Takashi
Radgenomics Research Group National Institute Of Radiological Sciences
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Imai Takashi
放射線医学総合研究所フロンティア研究センター 放射線感受性遺伝子プロジェクト
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Saegusa Kumiko
Radgenomics Project Frontier Research Center National Institute Of Radiological Sciences
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Imai Takashi
University Of Tokyo
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SHIMADA Yutaka
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni
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Imai Takashi
National Inst. Radiological Sci. Chiba Jpn
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Koyama-saegusa Kumiko
Frontier Res. Center National Inst. Of Radiological Sciences
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BAN Sadayuki
RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences
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ISHIKAWA Kenichi
RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences
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KAWAI Seiko
RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences
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ISHIKAWA Atsuko
RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences
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INAZAWA Johji
Institute for Molecular Cytogenetics, Tokyo Medical and Dental University
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Ban Sadayuki
Radgenomics Project Frontier Research Center National Institute Of Radiological Sciences
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Izumi Takashi
Dept. Of Biochem. Gunma Univ. Graduate Sch. Med.
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Inazawa Johji
Institute For Molecular Cytogenetics Tokyo Medical And Dental University
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ISHIKAWA Takahiro
Natl Inst Radiol Sci
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Imai Takashi
Dept. Of Biochem. Gunma Univ. Graduate Sch. Med.
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Imai T
Rf Heating Laboratory Naka Fusion Research Establishment Japan Atomic Energy Research Institute
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Ishikawa Atsuko
Radgenomics Project Frontier Research Center National Institute Of Radiological Sciences
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Shimada Yutaka
Department Of Anatomy And Cell Biology School Of Medicine Chiba Unversity
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Kawai Seiko
Radgenomics Project Frontier Research Center National Institute Of Radiological Sciences
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Ishikawa Kenichi
Radgenomics Project Frontier Research Center National Institute Of Radiological Sciences
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Shimada Yutaka
Department Of Anatomy And Cell Biology School Of Medicine Chiba University
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Imai Takashi
Frontier Res. Ctr. Nirs
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Imai Takashi
Radgenomics Project National Institute Of Radiological Sciences
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Ishikawa Ken-ichi
RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences
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