Fractionated Irradiation Augments Inter-Strain Variation of Skin Reactions among Three Strains of Mice

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概要

• 論文の詳細を見る

• The multifraction regimens commonly used in conventional clinical radiotherapy are largely based on radiobiological experiments. However, no experimental reports on skin reactions focusing on interstrain differences have displayed clinical relevance to the fractionated dose schedule. In this study, mice of inbred strains A/J, C57BL/6J, and C3H/HeMs were used to reveal inter-strain difference after multifractionated irradiation. Irradiation was performed daily at graded doses of 30-60 Gy total doses, with 10 fractions of 3-6 Gy. Acute skin reactions following irradiation were scored for 50 days after irradiation. Dividing a dose into a number of fractions obviously spared skin damage in the three strains of mice. No mouse exhibited a skin damage score more than 1.5, while single dose irradiation resulted in skin damage scores up to 3. The three different strains, however, showed varying susceptibility to fractionated irradiation within the range under 1.5. C3H/HeMs did not display any skin reaction after irradiation with 40 Gy total dose, while C57BL/6J and A/J demonstrated various skin reactions. Different latent periods of damage were also observed among the strains after irradiation at each dose. Our data suggest that genetic factors cause obvious variations in severity of damage and latent period after fractionated irradiation.

• 日本放射線影響学会の論文

著者

• IMAI Takashi

  Frontier Res. Ctr., NIRS

• Ohno Tatsuya

  放射線医学総合研究所重粒子医科学センター病院

• Imai Takashi

  Radgenomics Research Group National Institute Of Radiological Sciences

• Imai Takashi

  放射線医学総合研究所フロンティア研究センター 放射線感受性遺伝子プロジェクト

• Imai Takashi

  University Of Tokyo

• Imai Takashi

  National Inst. Radiological Sci. Chiba Jpn

• NODA Shuhei

  RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences

• IWAKAWA Mayumi

  Frontier Research Center

• GOTO Miyako

  Frontier Research Center

• NODA Shuhei

  Frontier Research Center

• HARADA Yoshinobu

  Frontier Research Center, National Institute of Radiological Sciences (NIRS)

• OHTA Toshie

  Frontier Research Center, National Institute of Radiological Sciences

• OOHIRA Chisa

  Frontier Research Center, National Institute of Radiological Sciences

• MINFU Yang

  Frontier Research Center, National Institute of Radiological Sciences

• TANAKA Hiroko

  Frontier Research Center, National Institute of Radiological Sciences

• OOHIRA Chisa

  RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences

• Izumi Takashi

  Dept. Of Biochem. Gunma Univ. Graduate Sch. Med.

• ISHIKAWA Takahiro

  Natl Inst Radiol Sci

• Oohira Chisa

  放射線医学総合研究所

• Oohira Chisa

  Radgenomics Project National Institute Of Radiological Sciences

• Ohira Chisa

  Radgenomics Project Frontier Research Center National Institute Of Radiological Sciences

• Hirama Toshiyasu

  Research Center For Charged Particle Therapy National Institute Of Radiological Sciences

• Imai Takashi

  Dept. Of Biochem. Gunma Univ. Graduate Sch. Med.

• Imai T

  Rf Heating Laboratory Naka Fusion Research Establishment Japan Atomic Energy Research Institute

• Noda Syuhei

  Radgenomics Project Frontier Research Center National Institute Of Radiological Sciences

• Noda Shuhei

  Radgenomics Project Frontier Research Center National Institute Of Radiological Sciences

• Iwakawa Mayumi

  Radgenomics Research Group National Institute Of Radiological Sciences

• Minfu Yang

  Frontier Research Center National Institute Of Radiological Sciences

• Goto Miyako

  Frontier Research Center National Institute Of Radiological Sciences

• Ohta Toshie

  Radgenomics Research Group National Institute Of Radiological Sciences

• Harada Yoshinobu

  Frontier Research Center National Institute Of Radiological Sciences

• Ohno Tatsuya

  Department Of Radiation Oncology Graduate School Of Medicine Gunma University

• Iwakawa Mayumi

  Res. Center For Charged Particle Therapy National Inst. Of Radiological Sciences

• Imai Takashi

  Frontier Res. Ctr. Nirs

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