High-dose-rate Interstitial Brachytherapy with Computed Tomography-based Treatment Planning for Patients with Locally Advanced Uterine Cervical Carcinoma
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概要
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The aims of this study were to carry out a dose volume analysis of high-dose-rate interstitial brachytherapy with computed tomography-based treatment planning and to investigate the treatment outcome of patients with locally advanced bulky and/or irregularly shaped uterine cervical carcinoma. Between July 2003 and December 2007, 15 patients were treated with external beam radiation therapy and high-dose-rate interstitial brachytherapy with or without intracavitary brachytherapy. Seven patients were treated with interstitial brachytherapy alone, and 8 were treated with combined use of intracavitary and interstitial brachytherapy. A comparison of the volume and dose parameters with intracavitary and interstitial brachytherapy in patients who received both treatments showed that the median D90 of the high-risk clinical target volume per fraction was 4.4 Gy with intracavitary brachytherapy and 5.6 Gy with interstitial brachytherapy, and the median V100 was 66% with intracavitary brachytherapy and 85% with interstitial brachytherapy. The median D2cc of the bladder with intracavitary and interstitial brachytherapy per fraction was 5.5 Gy and 4.7 Gy, respectively, and the median D2cc of the rectum with intracavitary and interstitial brachytherapy was 5.9 Gy and 4.1 Gy, respectively. The median follow-up time was 37 months, and the overall and progression-free survival rates for all patients at 3 years were 78% and 51%, respectively. The actuarial 2-year and 3-year locoregional control rates were 80% and 71%, respectively. Dose distribution was improved with image-based interstitial brachytherapy, and satisfactory local control was achieved for patients with locally advanced uterine cervical carcinoma in which intracavitary brachytherapy may result in a suboptimal dose distribution.
- Journal of Radiation Research 編集委員会の論文
著者
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Ohno Tatsuya
放射線医学総合研究所重粒子医科学センター病院
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Noda Shin-ei
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
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Nakano Takashi
Department Of Anatomy Aichi Medical University
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Suzuki Yoshiyuki
Department Of Hepatology Toranomon Hospital
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Sakurai Hideyuki
Department Of Radiology And Radiation Oncology Gunma University School Of Medicine
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Sakurai Hideyuki
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
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Takahashi Takeo
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
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Saitoh Jun-ichi
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
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Wakatsuki Masaru
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
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Katoh Hiroyuki
Department Of Gastroenterology Hokkaido University Graduate School Of Medicine
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Ohno Tatsuya
Department Of Radiation Oncology Graduate School Of Medicine Gunma University
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SIBUYA Kei
Department of Radiation Oncology, Gunma University Graduate School of Medicine
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Suzuki Yoshiyuki
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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