In Vitro Activities of 11 Antimicrobial Agents against Macrolide-Resistant Mycoplasma pneumoniae Isolates from Pediatric Patients: Results from a Multicenter Surveillance Study
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概要
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Macrolide-resistant Mycoplasma pneumoniae is emerging in several countries, and it is mainly observed in children. To our knowledge, we conducted the first multicenter prospective epidemiological study of macrolide-resistant M. pneumoniae in order to investigate regional differences in the susceptibility of macrolide-resistant M. pneumoniae to antibacterial agents. The in vitro activities of 11 antimicrobial agents against macrolide-resistant M. pneumoniae isolates from 5 different areas of Japan were investigated. Among 190 M. pneumoniae isolates from pediatric patients, 124 (65.2%) isolates showed macrolide resistance and possessed an A2063G transition in domain V of the 23S rRNA. These isolates showed high resistance to erythromycin, clarithromycin, and azithromycin with minimum inhibitory concentrations (MICs) ≥16 μg/ml. Conversely, quinolones such as garenoxacin, moxifloxacin, tosufloxacin, and levofloxacin exhibited potent antimycoplasmal activity. No regional differences were observed with respect to the MICs among the 5 areas in Japan.
著者
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Terada Kihei
Department Of Pediatrics Kawasaki Medical School
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Kawasaki Kozo
Department Of Pediatrics Yamaguchi University School Of Medicine
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Nakano Takashi
Department Of Anatomy Aichi Medical University
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KAWAI Yasuhiro
Department of Pediatrics, Kawasaki Medical School
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Ogita Satoko
Department Of Pediatrics Kawasaki Medical School
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Ouchi Kazunobu
Department Of Paediatrics Saiseikai Shimonoseki General Hospital
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Kawai Yasuhiro
Department Of Pediatrics Kawasaki Medical School
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Akaike Hiroto
Department Of Applied Chemistry School Of Engineering The University Of Tokyo
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Tanaka Takaaki
Department Of Bioscience & Biotechnology Faculty Of Engineering Okayama University
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Kubo Mika
Department Of Biology Faculty Of Science Kochi University
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Miyashita Naoyuki
Department Of General Internal Medicine 1 Kawasaki Hospital Kawasaki Medical School
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Miyashita Naoyuki
Department of Internal Medicine 1, Kawasaki Medical School
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Kawasaki Kozo
Department of Pediatrics, Kawasaki Medical School
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Tanaka Takaaki
Department of Pediatrics, Kawasaki Medical School
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Akaike Hiroto
Department of Pediatrics, Kawasaki Medical School
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Kubo Mika
Department of Pediatrics, Kawasaki Medical School
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