Higher pAkt Expression Predicts a Significant Worse Prognosis in Glioblastomas
スポンサーリンク
概要
- 論文の詳細を見る
phosphorylated-Akt (pAkt) plays an important role in tumorigenesis through promotion of cell survival by inhibiting apoptosis and mediating cell proliferation. Higher expression of pAkt has been reported to be associated with an unfavorable prognosis in several malignant tumors. In this study, the prognostic value of pAkt expression was investigated in glioblastomas by using immunohistochemical methods. Tissue sections obtained from 64 patients with glioblastoma were evaluated. The mean and median follow-up period was 16.2 ± 12.4 and 12 months, respectively (range: from 1 to 62 months). pAkt expression levels were determined by immunohistochemical staining and evaluated for cell positivity. Positive staining was defined when more than 50% of the tumor cells were stained in each section. The correlation between expression of pAkt and overall survival rate was assessed. Glioblastomas showed either or both cytoplasmic and nuclear positive findings for pAkt. A total of 29.7% (19/64) of tissue specimens had greater than 50% positivity. The median survival periods of the patients with pAkt positive and negative tumor were 10 and 14 months, respectively. Two years overall survival rate of the pAkt positive and negative patients were 0% and 24.4%, respectively. Survival rate of the patients with pAkt positive tumor was significantly lower than that of the patients with pAkt negative tumors (p = 0.004). Multivariate analysis showed that extent of surgery was the strongest factor for survival (p = 0.01) and the pAkt expression was the secondly strongest factor (p = 0.06). These results suggest that the higher expression of pAkt the poorer prognosis in patients with glioblastoma.
- Journal of Radiation Research 編集委員会の論文
- 2010-05-16
著者
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NAKANO Takashi
Department of Physics, Kyoto University
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SUZUKI Yoshiyuki
Department of Radiation Oncology, Gunma University Graduate school of Medicine
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YOSHIDA Yukari
Gunma University Heavy Ion Medical Center
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Suzuki Yoshihiko
Division of Cardiology, Department of Internal Medicine, National, Cardiovascular Center
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SHIRAI Katsuyuki
Department of Radiation Oncology, Gunma University Graduate School of Medicine
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OKAMOTO Masahiko
Department of Radiation Oncology, Gunma University Graduate School of Medicine
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NODA Shin-ei
Department of Radiation Oncology, Gunma University Graduate School of Medicine
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ISHIUCHI Shogo
Department of Neurosurgery, Faculty of Medicine, University of the Ryukyus
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Shirai K
Division Of Applied Biology Faculty Of Textile Science And Technology Shinshu University
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Noda Shin-ei
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
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Nakano T
Centrifuge Project Team Nasda
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Yoshida Yukari
Department Of Neurophysiology Gunma University Graduate School Of Medicine
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Ishiuchi Shogo
Department Of Neurosurgery Faculty Of Medicine University Of Ryukyus
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Nakano Takashi
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
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Nakano Takashi
Department Of Anatomy Aichi Medical University
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Nakano Takashi
Department Of Radiology And Radiation Oncology Gunma University Graduate School Of Medicine
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OKA Kuniyuki
Department of Medical Examination, Mito Saiseikai General Hospital
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Shirai Katsuyuki
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
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Suzuki Yoshiyuki
Department Of Hepatology Toranomon Hospital
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Suzuki Yoshiyuki
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
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Okamoto Masahiko
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
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Itoh Hideaki
Section Of Pathology Maebashi Red Cross Hospital
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Nonaka Tetsuo
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
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Nonaka Tetsuo
Department Of Radiology Gunma Cancer Center
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MOBARAKI Abdulelah
Department of Radiation Oncology, Gunma University Graduate School of Medicine
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ITOH Jun
Section of Radiology, Maebashi Red Cross Hospital
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Shibuya Kei
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
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Okamoto Masahiko
Department Of Cardiovascular Surgery Kawasaki Municipal Hospital
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Tanaka Naritaka
Department Of General Surgical Science (surgery I) Gunma University Graduate School Of Medicine
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Nakazawa Tsugio
Department Of Tumor Pathology Gunma University Graduate School Of Medicine
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Suzuki Keiji
Atomic Bomb Disease Institute Graduate School Of Biomedical Sciences Nagasaki University
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Suzuki Yoshiyuki
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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Oka Kuniyuki
Department Of Pathology Mito Saiseikai General Hospital
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Mobaraki Abdulelah
Department Of Radiation Oncology Graduate School Of Medicine Gunma University
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Mobaraki Abdulelah
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
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Itoh Jun
Section Of Radiology Maebashi Red Cross Hospital
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Shibuya Kei
Dep. Of Radiation Oncology Gunma Univ. Graduate School Of Medicine
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Suzuki Yoshiyuki
Department Of Applied Physics Tohoku University
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Shirai Katsuyuki
Department Of Radiation Oncology Gunma Prefectural Cancer Center
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