Hepatocarcinogenesis Following HCV RNA Eradication by Interferon in Chronic Hepatitis Patients
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概要
- 論文の詳細を見る
Objective Interferon (IFN) therapy reduces the incidence of hepatocarcinogenesis in patients with hepatitis C viral (HCV) infection who achieve a sustained virological response (SVR). The aim of the present study was to determine the rate of hepatocarcinogenesis and the risk factor in sustained virological responders. Patients and Method The study subjects were 1,193 patients with HCV-related chronic liver disease and IFN- or IFN plus ribavirin-induced SVR. The age, male/female ratio, and liver fibrosis stage [(F0-F3)/LC] were 15-83 years, 808/385, and 1106/41, respectively. Patients were followed-up for 8.3 years (range, 0 to 19.0 years) and the incidence of hepatocellular carcinoma was recorded. Results Hepatocellular carcinogenesis was detected in 23 patients during the follow-up. The crude rates of hepatocarcinogenesis at 5, 10, and 15 years were 1.5%, 2.4% and 4.1%, respectively. Multivariate analysis identified cirrhosis, male sex and age older than 50 years as determinants of hepatocarcinogenesis with hazard ratios of 12.9 (p<0.001), 6.45 (p=0.012), and 20.2 (p=0.004), respectively. Conclusion Long-term follow-up of patients with chronic HCV infection is necessary even in those who show SVR, especially in male elderly patients with cirrhosis.
- 社団法人 日本内科学会の論文
著者
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SUZUKI Yoshiyuki
Department of Radiation Oncology, Gunma University Graduate school of Medicine
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Saitoh Satoshi
Department of Cardiology, Nihon University School of Medicine
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Saitoh Satoshi
Department Of Hepatology Toranomon Hospital
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KUMADA Hiromitsu
Department of Hepatology, Toranomon Hospital
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Kumada Hiromitsu
Department Of Gastroenterology Toranomon Hospital
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Sezaki Hitomi
Department Of Hepatology Toranomon Hospital
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KAWAMURA Yusuke
Department of Hepatology, Toranomon Hospital
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IKEDA Kenji
Department of Hepatology, Toranomon Hospital
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HIRAKAWA Miharu
Department of Hepatology, Toranomon Hospital
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HOSAKA Tetsuya
Department of Hepatology, Toranomon Hospital
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KOBAYASHI Masahiro
Department of Hepatology, Toranomon Hospital
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YATSUJI Hiromi
Department of Hepatology, Toranomon Hospital
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AKUTA Norio
Department of Hepatology, Toranomon Hospital
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SUZUKI Fumitaka
Department of Hepatology, Toranomon Hospital
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ARASE Yasuji
Department of Hepatology, Toranomon Hospital
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Kawamura Yusuke
Department Of Hepatology Toranomon Hospital
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Yatsuji Hiromi
Department Of Hepatology Toranomon Hospital
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Hosaka Tetsuya
Department Of Gastroenterology Toranomon Hospital
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Arase Yasuji
Department Of Gastroenterology Toranomon Hospital
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Akuta Norio
Department Of Gastroenterology Toranomon Hospital
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Suzuki Fumitaka
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Ikeda Kenji
Department De Genie Chimique Universite Nationale De Yokohama
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Kobayashi Masahiro
Department Of Chest Surgery Kitakyushu City Yahata Hospital
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Suzuki Yoshiyuki
Department Of Applied Physics Tohoku University
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Saitoh Satoshi
Department Of Advanced Medical Science Nihon University School Of Medicine
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Hirakawa Miharu
Department of Hepatology and Okinaka Memorial Institute for Medical Research, Toranomon Hospital
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Kawamura Yusuke
Department of Hepatology and Okinaka Memorial Institute for Medical Research, Toranomon Hospital
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