Current Advancement in Radiation Therapy for Uterine Cervical Cancer
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概要
- 論文の詳細を見る
Radiation therapy is one of the effective curative treatments for uterine cervical cancer. However poor clinical results for the advanced stages require further improvement of the treatment. Intensive studies on basic and clinical research have been made to improve local control, primarily important for long term survival in radiation therapy. Regarding current advancement in radiation therapy for uterine cervical cancer, the following three major subjects are pointed out; technological development to improve dose distribution by image guided radiation therapy technology, the concomitant anticancer chemotherapy with combination of radiation therapy, and radiation biological assessment of the radiation resistance of tumors. The biological factors overviewed in this article include hypoxia relating factors of HIF-1α, SOD, cell cycle parameters of pMI, proliferation factors of Ki67, EGFR, cerbB2, COX-2, cycle regulation proteins p53, p21, apoptosis regulation proteins Bcl2 and Bax and so on. Especially, the variety of these radiation biological factors is important for the selection of an effective treatment method for each patient to maximize the treatment benefit.
- 2010-01-16
著者
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NAKANO Takashi
Department of Physics, Kyoto University
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OHNO Tatsuya
Department of Radiation Oncology, Gunma University Graduate school of Medicine
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ISHIKAWA Hitoshi
Department of Radiation Oncology, Gunma University Graduate school of Medicine
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SUZUKI Yoshiyuki
Department of Radiation Oncology, Gunma University Graduate school of Medicine
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TAKAHASHI Takeo
Department of Radiation Oncology, Gunma University Graduate school of Medicine
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Ohno Tatsuya
放射線医学総合研究所重粒子医科学センター病院
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Ohno Tatsuya
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
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Nakano T
Centrifuge Project Team Nasda
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Nakano Takashi
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
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Nakano Takashi
Department Of Anatomy Aichi Medical University
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Nakano Takashi
Department Of Radiology And Radiation Oncology Gunma University Graduate School Of Medicine
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Ikehira H
Department Of Medical Imaging National Institute Of Radiological Sciences
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Ikehira Hiroo
Division Of Advanced Technology For Medical Imaging Research Center Of Charged Particle Technique Na
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Tamaki Tomoaki
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
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Ishikawa Hitoshi
Department Of Orthopedic Surgery Kobe University School Of Medicine
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Suzuki Yoshiyuki
Department Of Hepatology Toranomon Hospital
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Suzuki Yoshiyuki
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
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Taketomi Takahashi
Department Of Diagnostic Radiology And Nuclear Medicine Gunma University Graduate School Of Medicine
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Ishikawa Hitoshi
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
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Nonaka Tetsuo
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
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Nonaka Tetsuo
Department Of Radiology Gunma Cancer Center
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Takahashi Takeo
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
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Tanaka Naritaka
Department Of General Surgical Science (surgery I) Gunma University Graduate School Of Medicine
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Ohno Tatsuya
Department Of Radiation Oncology Graduate School Of Medicine Gunma University
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Suzuki Yoshiyuki
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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Ishikawa Hitoshi
Department Of Mechanical Engineering Tokyo University Of Science
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Takahashi Takeo
Department Of Anesthesiology Sapporo Medical College And Hospital
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Takahashi T
Department Of Radiation Oncology Gunma University Graduate School Of Medicine
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Suzuki Yoshiyuki
Department Of Applied Physics Tohoku University
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Ishikawa Hitoshi
Department of Electrical Engineering, College of Science and Technology, Nihon University, Chiyoda, Tokyo 101-8308, Japan
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